6-Hydroxychlorzoxazone
SIGMA/UC148 - ≥98% (HPLC)
Synonym: 5-
CAS Number: 1750-45-4
Empirical Formula (Hill Notation): C7H4ClNO3
Molecular Weight: 185.56
MDL Number: MFCD00143502
Linear Formula: C7H4ClNO3
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to pink |
| form | solid |
| InChI | 1S/C7H4ClNO3/c8-3-1-4-6(2 |
| InChI key | AGLXDWOTVQZHIQ-UHFFFAOYSA |
| Quality Level | 200  |
| SMILES string | Oc1cc2OC(=O)Nc2cc1Cl |
| solubility | methanol: soluble |
| storage temp. | 2-8°C |
| Application: | 6-hydroxy Chlorzoxazone has been used: as a reference standard to monitor substrate depletion or 6-hydroxy chlorzoxazone formation by cytochrome P450 family 2 subfamily E member 1 (CYP2E1)in recombinant human enzyme screening. 6-Hydroxychlorzoxazone has been used for high-performance liquid chromatography (HPLC)-based metabolic assays of chlorzoxazone. |
| Application: | 6-Hydroxychlorzoxazone has been used for HPLC-based metabolic assays of chlorzoxazone. |
| Application: | CYP2E1 & 1A2 metabolite of chlorzoxazone. |
| Biochem/physiol Actions: | 6-hydroxy Chlorzoxazone is a novel metabolite of chlorzoxazone. It is formed by the hydroxylation of chlorzoxazone by cytochrome P450 family 2 subfamily E member 1 (CYP2E1) enzyme. The determination of formation and clearance of 6-hydroxychlorzoxazone is used as a reliable marker of CYP2E1 metabolic activity. |
| Packaging: | 5, 10 mg in glass bottle |
| Packaging: | Bottomless glass bottle. Contents are inside inserted fused cone. |
| Preparation Note: | 6-Hydroxychlorzoxazone is soluble in methanol. |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315 - H319 - H335 |
| Precautionary statements | P302 + P352 - P305 + P351 + P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12161501 |