Oxidized Nifedipine
SIGMA/UC167 - powder, ~95% (HPLC)
Synonym: 2,6-
CAS Number: 67035-22-7
Empirical Formula (Hill Notation): C17H16N2O6
Molecular Weight: 344.32
MDL Number: MFCD00153847
Linear Formula: C17H16N2O6
Product Type: Chemical
assay | ~95% (HPLC) |
color | yellow |
form | powder |
InChI | 1S/C17H16N2O6/c1-9-13(16( |
InChI key | UMQHJQGNGLQJPF-UHFFFAOYSA |
mp | 100-105 °C |
SMILES string | COC(=O)c1c(C)nc(C)c(C(=O) |
storage temp. | 2-8°C |
Application: | Oxidized nifedipine has been used for apoptotic signaling studies in dopaminergic neurons. |
Application: | Oxidized Nifedipine may be used: • to study enzyme kinetics using UV high-performance liquid chromatography (UV-HPLC) • as a standard in calibration curve preparation in high-performance liquid chromatography (HPLC) for the quantification of cytochrome P450 3A4 (CYP3A4)-mediated nifedipine oxidation in human microsomes • in nifedipine metabolism activity assay of Hep G2 cells transfected with hepatocyte nuclear factor-1α(HNF1α) |
Biochem/physiol Actions: | CYP3A4 nifedipine metabolite. Nifedipine (parent compound) is an antianginal and antihypertensive agent. |
Biochem/physiol Actions: | Nifedipine is a dihydropyridine derivative and a calcium channel blocker. It is used in treating hypertension and angina pectoris. Oxidized Nifedipine is an oxidation product of nifedipine generated either by exposure to UV or day light. The enzyme cytochrome P450 3A (CYP3A4) metabolizes nifedipine. |
Other Notes: | Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. UC167.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin. |
Packaging: | 5, 10 mg in glass bottle |
Packaging: | Bottomless glass bottle. Contents are inside inserted fused cone. |
Symbol | GHS05 |
Signal word | Danger |
Hazard statements | H318 |
Precautionary statements | P280 - P305 + P351 + P338 |
Hazard Codes | Xi |
Risk Statements | 41 |
Safety Statements | 26-39 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 2 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ~95% (HPLC) |
mp | 100-105 °C |
Storage Temp. | 2-8°C |
UNSPSC | 12161501 |