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Oxidized Nifedipine

SIGMA/UC167 - powder, ~95% (HPLC)

Synonym: 2,6-Dimethyl-4-(2ยด-nitrophenyl)-3,5-pyridinecarboxylic acid dimethyl ester

CAS Number: 67035-22-7
Empirical Formula (Hill Notation): C17H16N2O6
Molecular Weight: 344.32
MDL Number: MFCD00153847
Linear Formula: C17H16N2O6
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-UC167-5MG 5 mg
 $482.00
1/EA		 Add To Favorites
45-UC167-10MG 10 mg
 $885.00
1/EA		 Add To Favorites

 

assay ~95% (HPLC)
color yellow
form powder
InChI 1S/C17H16N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8H,1-4H3
InChI key UMQHJQGNGLQJPF-UHFFFAOYSA-N
mp 100-105 °C
Quality Level 200 
SMILES string COC(=O)c1c(C)nc(C)c(C(=O)OC)c1-c2ccccc2[N+]([O-])=O
storage temp. 2-8°C
Application: Oxidized nifedipine has been used for apoptotic signaling studies in dopaminergic neurons.
Application: Oxidized Nifedipine may be used:
• to study enzyme kinetics using UV high-performance liquid chromatography (UV-HPLC)
• as a standard in calibration curve preparation in high-performance liquid chromatography (HPLC) for the quantification of cytochrome P450 3A4 (CYP3A4)-mediated nifedipine oxidation in human microsomes
• in nifedipine metabolism activity assay of Hep G2 cells transfected with hepatocyte nuclear factor-1α(HNF1α)
Biochem/physiol Actions: CYP3A4 nifedipine metabolite. Nifedipine (parent compound) is an antianginal and antihypertensive agent.
Biochem/physiol Actions: Nifedipine is a dihydropyridine derivative and a calcium channel blocker. It is used in treating hypertension and angina pectoris. Oxidized Nifedipine is an oxidation product of nifedipine generated either by exposure to UV or day light. The enzyme cytochrome P450 3A (CYP3A4) metabolizes nifedipine.
Packaging: 5, 10 mg in glass bottle
Packaging: Bottomless glass bottle. Contents are inside inserted fused cone.
Symbol GHS05  GHS05
Signal word Danger
Hazard statements H318
Precautionary statements P280 - P305 + P351 + P338
Hazard Codes Xi
Risk Statements 41
Safety Statements 26-39
RIDADR NONH for all modes of transport
WGK Germany WGK 2
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ~95% (HPLC)
mp 100-105 °C
Storage Temp. 2-8°C
UNSPSC 12161501

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