[deamino-Cys¹, D-Arg⁸]-Vasopressin acetate salt hydrate

SIGMA/V1005 - ≥95% (HPLC)

Synonym: DDAVP; Desmopressin

CAS Number: 16679-58-6 (free base)
Empirical Formula (Hill Notation): C₄₆H₆₄N₁₄O₁₂S₂ · xC₂H₄O₂ · yH₂O
Molecular Weight: 1069.22 (anhydrous free base basis)
Linear Formula: C₄₆H₆₄N₁₄O₁₂S₂ · xC₂H₄O₂ · yH₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-V1005-.1MG	0.1 mg	$80.40 1/EA	Add To Favorites
45-V1005-.5MG	0.5 mg	$246.00 1/EA	Add To Favorites
45-V1005-1MG	1 mg	$401.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥95% (HPLC)
biological source	synthetic (organic)
form	powder
InChI	1S/C46H64N14O12S2.C2H4O2.H2O/c47-35(62)15-14-29-40(67)58-32(22-36(48)63)43(70)59-33(45(72)60-18-5-9-34(60)44(71)56-28(8-4-17-52-46(50)51)39(66)53-23-37(49)64)24-74-73-19-16-38(65)54-30(21-26-10-12-27(61)13-11-26)41(68)57-31(42(69)55-29)20-25-6-2-1-3-7-25;1-2(3)4;/h1-3,6-7,10-13,28-34,61H,4-5,8-9,14-24H2,(H2,47,62)(H2,48,63)(H2,49,64)(H,53,66)(H,54,65)(H,55,69)(H,56,71)(H,57,68)(H,58,67)(H,59,70)(H4,50,51,52);1H3,(H,3,4);1H2/t28-,29+,30+,31+,32+,33+,34+;;/m1../s1
InChI key	KWCKGAOCVGPZIC-VCCVNBJCSA-N
Quality Level	200
shipped in	ambient
SMILES string	O.CC(O)=O.NC(=N)NCCC[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H](Cc4ccccc4)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O
solubility	H₂O: soluble 20 mg/mL, clear, colorless
sterility	non-sterile
storage temp.	−20°C

Amino Acid Sequence:	Mpa-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2 [Disulfide Bridge: 1-6]
Application:	[deamino-Cys1, D-Arg8]-Vasopressin acetate salt hydrate has been used: • in induction of antidiuresis • as agonist of V2-receptor (V2R) • for Von Willebrand factor (VWF) secretion in bleeding diathesis
Application:	[deamino-Cys1, D-Arg8]-Vasopressin acetate salt hydrate was used to study the impact of vasopressin on pendrin abundance. E3 ubiquitin (Ub)-protein ligases (E3s) was administered in rat kidney and the changes in protein abundance of the selected E3s in response to [deamino-Cys1, D-Arg8]-Vasopressin acetate salt hydrate was examined.
Biochem/physiol Actions:	[deamino-Cys1, D-Arg8]-Vasopressin acetate salt hydrate also known as DDAVP, Desmopressin is a selective and potent vasopressor agent that stabilizes the cardiocirculatory function in normal human as well as in patients suffering from catecholamine-resistant vasodilatory shock. It also stimulate three acid-base transporters and hence increases the capability of the cell to regulate pH.
Preparation Note:	[deamino-Cys1, D-Arg8]-Vasopressin acetate salt hydrate dissolves in water at 20 mg/ml to yield a clear, colorless solution.

Symbol	GHS07
Signal word	Warning
Hazard statements	H332
Precautionary statements	P304 + P340 + P312
Hazard Codes	Xn
Risk Statements	20
Safety Statements	36
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥95% (HPLC)
Storage Temp.	−20°C
UNSPSC	51111800

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