R(+)-Verapamil monohydrochloride hydrate
SIGMA/V106 - ≥98% (HPLC), powder
CAS Number: 38176-02-2 (anhydrous)
Empirical Formula (Hill Notation): C27H38N2O4 · HCl · xH2O
Molecular Weight: 491.06 (anhydrous basis)
EC Number: 205-800-5
MDL Number: MFCD11046028
Linear Formula: C27H38N2O4 · HCl · xH2O
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white |
form | powder |
InChI | 1S/C27H38N2O4.ClH.H2O/c1- |
InChI key | ICKXRKHJKXMFLR-KFSCGDPASA |
optical activity | [α]22/D +9.6°, c = 0.5 in ethanol(lit.) |
Quality Level | 100 |
SMILES string | O.Cl.COc1ccc(CCN(C)CCC[C@ |
solubility | ethanol: soluble |
H2O: >30 mg/mL | |
storage condition | desiccated |
Application: | R(+)-Verapamil monohydrochloride hydrate has been used as a P-glycoprotein (gp) inhibitor, to detect P-gp expression on the SK-OV-3 and SK-OV-3/DDP cell surface by flow cytometry. It has also been used as a calcium channel blocker, to evaluate its effect on doxorubicin (DOX) cytotoxicity. |
Biochem/physiol Actions: | Inhibitor of P-glycoprotein; less active enantiomer of (±)-verapamil. |
Biochem/physiol Actions: | Verapamil is a calcium channel blocker. Verapamil hydrochloride is a phenyl-alkyl amine derivative and is potentially used for treating hypertension, angina pectoris and arrhythmias. It is water soluble in nature. |
Caution: | hygroscopic |
Packaging: | 5, 25 mg in glass bottle |
Symbol | GHS06 |
Signal word | Danger |
Hazard statements | H301 + H311 + H331 |
Precautionary statements | P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311 |
Hazard Codes | T |
Risk Statements | 23/24/25 |
Safety Statements | 22-36/37/39-45 |
RIDADR | UN 2811 6.1 / PGIII |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
UNSPSC | 12161501 |