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R(+)-Verapamil monohydrochloride hydrate

SIGMA/V106 - ≥98% (HPLC), powder

CAS Number: 38176-02-2 (anhydrous)
Empirical Formula (Hill Notation): C27H38N2O4 · HCl · xH2O
Molecular Weight: 491.06 (anhydrous basis)
EC Number: 205-800-5
MDL Number: MFCD11046028
Linear Formula: C27H38N2O4 · HCl · xH2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-V106-5MG 5 mg
 $276.00
1/EA		 Add To Favorites
45-V106-25MG 25 mg
 $1040.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white
form powder
InChI 1S/C27H38N2O4.ClH.H2O/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H;1H2/t27-;;/m1../s1
InChI key ICKXRKHJKXMFLR-KFSCGDPASA-N
optical activity [α]22/D +9.6°, c = 0.5 in ethanol(lit.)
Quality Level 100 
SMILES string O.Cl.COc1ccc(CCN(C)CCC[C@@](C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC
solubility ethanol: soluble
  H2O: >30 mg/mL
storage condition desiccated
Application: R(+)-Verapamil monohydrochloride hydrate has been used as a P-glycoprotein (gp) inhibitor, to detect P-gp expression on the SK-OV-3 and SK-OV-3/DDP cell surface by flow cytometry. It has also been used as a calcium channel blocker, to evaluate its effect on doxorubicin (DOX) cytotoxicity.
Biochem/physiol Actions: Inhibitor of P-glycoprotein; less active enantiomer of (±)-verapamil.
Biochem/physiol Actions: Verapamil is a calcium channel blocker. Verapamil hydrochloride is a phenyl-alkyl amine derivative and is potentially used for treating hypertension, angina pectoris and arrhythmias. It is water soluble in nature.
Disclaimer: hygroscopic
Packaging: 5, 25 mg in glass bottle
Purity ≥98% (HPLC)
UNSPSC 12161501

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