Vancomycin hydrochloride from Streptomyces orientalis
SIGMA/V1130 - BioReagent, suitable for plant cell culture
CAS Number: 1404-93-9
Empirical Formula (Hill Notation): C66H75Cl2N9O24 · HCl
Molecular Weight: 1485.71
Linear Formula: C66H75Cl2N9O24 · HCl
Product Type: Chemical
antibiotic activity spectrum | Gram-positive bacteria |
application(s) | agriculture |
biological source | Streptomyces orientalis |
color | , off-white to brown or White to orange-brown |
concentration | ≥900 μg/mg (as vancomycin base) |
form | powder |
mode of action | cell wall synthesis | interferes |
product line | BioReagent |
Quality Level | 200 |
SMILES string | Cl[H].CO[C@@H]1O[C@H](CO) |
solubility | H2O: 50 mg/mL, clear, colorless to dark yellow (and Very Faint Orange to Faint Orange) |
storage condition | (Keep container tightly closed in a dry and well-ventilated place.) |
storage temp. | 2-8°C |
technique(s) | cell culture | plant: suitable |
Application: | Vancomycin hydrochloride from Streptomyces orientalis has been used as: • an antibiotic in screening: minimal inhibitory concentrations (MICs) Streptomyces coelicolor • in treating Leishmania infected sand flies • in combined antibiotic treatment in asthma induced mice |
Biochem/physiol Actions: | Glycopeptide antibiotic Mode of action: Used to block bacterial cell wall biosynthesis at the level of peptidoglycan biosynthesis by inhibiting incorporation of terminal D-alanyl-D-alanine moieties of the NAM/NAG-peptides. Antimicrobial spectrum: Gram-positive bacteria |
Biochem/physiol Actions: | Vancomycin is used for treating methicillin-resistant Staphylococcus aureus (MRSA) infections and shunt-associated Staphylococcal ventriculitis. It may lead to hypersensitivity reactions like anaphylaxis and red man syndrome. Vanomycin is also used to treat thrombocytopenia and induces drug reaction with eosinophilia and systemic symptoms (DRESS) on usage. |
General description: | Chemical structure: glycopeptide |
General description: | Vancomycin is a heptapeptide. |
Other Notes: | Keep container tightly closed in a dry and well-ventilated place. |
Packaging: | 1, 5 g in glass bottle |
Symbol | GHS08 |
Signal word | Danger |
Hazard statements | H317 - H334 |
Precautionary statements | P261 - P272 - P280 - P284 - P302 + P352 - P304 + P340 + P312 |
Hazard Codes | Xi |
Risk Statements | 43 |
Safety Statements | 36/37 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 2 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |