Z-VAD-FMK
SIGMA/V116 - solid
Synonym: N-
CAS Number: 187389-52-2
Empirical Formula (Hill Notation): C22H30FN3O7
Molecular Weight: 467.49
MDL Number: MFCD01074990
Linear Formula: C22H30FN3O7
Product Type: Chemical
| assay | ≥98% (TLC) |
| biological source | synthetic |
| color | white |
| form | solid |
| Quality Level | 200  |
| solubility | DMSO: 20 mg/mL |
| H2O: insoluble | |
| storage temp. | −20°C |
| Application: | Z-VAD-FMK has been used: • to induce mixed-lineage kinase domain-like (MLKL) phosphorylation (p-MLKL) in L929 cells • to induce autophagy in Jurkat and K562 cells • to revert killing effects of oxaliplatin or oxaliplatin combination with chloroquine (CQ) on HCT116 and SW620 cell lines • as a caspase inhibitor to inhibit apoptosis and assess nuclear factor-kB, heat shock protein 70 (Hsp 70), proto-oncogene (cmyc) and tumor suppressor protein p53 |
| Biochem/physiol Actions: | Non-selective, cell permeable inhibitor of caspase-1- and caspase-3-related proteases. |
| Caution: | Hygroscopic |
| Features and Benefits: | This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| Features and Benefits: | This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| General description: | Z-VAD-FMK inhibits yeast and mammalian peptide N-glycanase (PNGase). It induces apoptosis. Z-VAD-FMK might be associated with endoplasmic reticulum (ER) stress. |
| Packaging: | Bottomless glass bottle. Contents are inside inserted fused cone. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (TLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |