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Z-VAD-FMK

SIGMA/V116 - solid

Synonym: N-Benzyloxycarbonyl-Val-Ala-Asp(O-Me) fluoromethyl ketone

CAS Number: 187389-52-2
Empirical Formula (Hill Notation): C22H30FN3O7
Molecular Weight: 467.49
MDL Number: MFCD01074990
Linear Formula: C22H30FN3O7
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-V116-2MG 2 mg
 $897.00
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This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥98% (TLC)
biological source synthetic
color white
form solid
InChI 1S/C22H30FN3O7/c1-13(2)19(26-22(31)33-12-15-8-6-5-7-9-15)21(30)24-14(3)20(29)25-16(17(27)11-23)10-18(28)32-4/h5-9,13-14,16,19H,10-12H2,1-4H3,(H,24,30)(H,25,29)(H,26,31)/t14-,16-,19-/m0/s1
InChI key MIFGOLAMNLSLGH-QOKNQOGYSA-N
Quality Level 200 
SMILES string FCC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)C)CC(=O)OC
solubility DMSO: 20 mg/mL
  H2O: insoluble
storage temp. −20°C
Application: Z-VAD-FMK has been used:
• to induce mixed-lineage kinase domain-like (MLKL) phosphorylation (p-MLKL) in L929 cells
• to induce autophagy in Jurkat and K562 cells
• to revert killing effects of oxaliplatin or oxaliplatin combination with chloroquine (CQ) on HCT116 and SW620 cell lines
• as a caspase inhibitor to inhibit apoptosis and assess nuclear factor-kB, heat shock protein 70 (Hsp 70), proto-oncogene (cmyc) and tumor suppressor protein p53
Biochem/physiol Actions: Non-selective, cell permeable inhibitor of caspase-1- and caspase-3-related proteases.
Disclaimer: Hygroscopic
Features and Benefits: This compound is a featured product for Apoptosis research. Click here  to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound is featured on the Caspases  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
General description: Z-VAD-FMK inhibits yeast and mammalian peptide N-glycanase (PNGase). It induces apoptosis. Z-VAD-FMK might be associated with endoplasmic reticulum (ER) stress.
Packaging: Bottomless glass bottle. Contents are inside inserted fused cone.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (TLC)
Storage Temp. −20°C
UNSPSC 12352209

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