Vinblastine sulfate salt

SIGMA/V1377 - ≥97% (HPLC)

Synonym: VLB; Vincaleukoblastine sulfate salt

CAS Number: 143-67-9
Empirical Formula (Hill Notation): C₄₆H₅₈N₄O₉ · H₂SO₄
Molecular Weight: 909.05
EC Number: 205-606-0
MDL Number: MFCD00082457
Linear Formula: C₄₆H₅₈N₄O₉ · H₂SO₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-V1377-1MG	1 mg	$39.50 1/EA		Add To Favorites
45-V1377-5MG	5 mg	$114.00 1/EA		Add To Favorites
45-V1377-10MG	10 mg	$159.00 1/EA		Add To Favorites
45-V1377-25MG	25 mg	$414.00 1/EA		Add To Favorites
45-V1377-50MG	50 mg	$697.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

absorption	14 at 270 nm in 0.1 M phosphate buffer at 1 mM
	16.2 at 259 nm in ethanol at 1 mM
	53.7 at 214 nm in ethanol at 1 mM
antibiotic activity spectrum	neoplastics
assay	≥97% (HPLC)
color	white to light yellow
form	(powder or amorphous or crystalline powder)
InChI	1S/C46H58N4O9.H2O4S/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7;1-5(2,3)4/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3;(H2,1,2,3,4)/t28-,37-,38+,39+,42-,43+,44+,45-,46-;/m0./s1
InChI key	KDQAABAKXDWYSZ-PNYVAJAMSA-N
mode of action	DNA synthesis \| interferes
mp	267 °C (dec.) (lit.)
originator	Eli Lilly
Quality Level	200
SMILES string	OS(O)(=O)=O.[H][C@@]12CN(CCc3c([nH]c4ccccc34)[C@@](C1)(C(=O)OC)c5cc6c(cc5OC)N(C)[C@@]7([H])[C@](O)([C@H](OC(C)=O)[C@]8(CC)C=CCN9CC[C@]67[C@]89[H])C(=O)OC)C[C@](O)(CC)C2
storage temp.	2-8°C

Application:	Vinblastine sulfate salt has been used: • as a microtubule depolymerizing drug for the synchronization of human cell lines in G2/M phase • as a multidrug resistance screening substrate in human colon cancer cell line (HCT116) cell line • as an antimicrotubule agent in sub perineural glia of Drosophila brain
Biochem/physiol Actions:	Plant alkaloid that inhibits microtubule assembly by binding tubulin and inducing self-association in spiral aggregates in a reaction that appears to be regulated by the C-terminus of β-tubulin and is enhanced by GDP and GTP. Depolymerizes microtubules. Arrests the cell cycle in G2/M-phase by blocking mitotic spindle formation. Triggers Raf-1 activation, phosphorylation of bcl-2-family proteins, induction of p53 expression, and apoptosis in several tumor cell lines. Substrate of Pgp and CYP3A4.
Features and Benefits:	This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits:	This compound was developed by Eli Lilly . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .

Symbol	GHS07,GHS08
Signal word	Warning
Hazard statements	H302 - H341 - H361fd
Precautionary statements	P201 - P301 + P312 + P330 - P308 + P313
Hazard Codes	Xn
Risk Statements	22-37/38-41
Safety Statements	26-36/39
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3

Purity	≥97% (HPLC)
mp	267 °C (dec.) (lit.)
Storage Temp.	2-8°C
UNSPSC	12352200

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