Valinomycin

SIGMA/V3639 - Ready Made Solution, ~1 mg/mL in DMSO

Synonym: Cyclo(L-Val-D-HyIva-D-Val-L-Lac-)₃: HyIva = α-Hydroxyisovaleric acid, Lac = Lactic acid

CAS Number: 2001-95-8
Empirical Formula (Hill Notation): C₅₄H₉₀N₆O₁₈
Molecular Weight: 1111.32
MDL Number: MFCD00005114
Linear Formula: C₅₄H₉₀N₆O₁₈
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-V3639-5ML	5 mL	$109.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	Gram-positive bacteria
	parasites
	viruses
assay	≥90% (HPLC)
biological source	Streptomyces sp.
color	colorless
concentration	~1 mg/mL in DMSO
form	liquid
InChI	1S/C54H90N6O18/c1-22(2)34-49(67)73-31(19)43(61)55-38(26(9)10)53(71)77-41(29(15)16)47(65)59-36(24(5)6)51(69)75-33(21)45(63)57-39(27(11)12)54(72)78-42(30(17)18)48(66)60-35(23(3)4)50(68)74-32(20)44(62)56-37(25(7)8)52(70)76-40(28(13)14)46(64)58-34/h22-42H,1-21H3,(H,55,61)(H,56,62)(H,57,63)(H,58,64)(H,59,65)(H,60,66)/t31-,32-,33-,34-,35+,36+,37-,38-,39-,40+,41+,42+/m0/s1
InChI key	FCFNRCROJUBPLU-RPUZOQEISA-N
mode of action	cell membrane \| interferes
Quality Level	200
shipped in	wet ice
SMILES string	CC(C)[C@@H]1NC(=O)[C@H](C)OC(=O)[C@@H](NC(=O)[C@H](OC(=O)[C@@H](NC(=O)[C@H](C)OC(=O)[C@H](NC(=O)[C@H](OC(=O)[C@@H](NC(=O)[C@H](C)OC(=O)[C@H](NC(=O)[C@H](OC1=O)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C
storage condition	(Keep container tightly closed in a dry and well-ventilated place. Hydroscopic.)
storage temp.	2-8°C

Application:	Valinomycin is a cyclic dodecadepsipeptides with potassium ionophoric properties. It is used to study ion transport in biological systems. It is used to study its inhibitory effect on intact cells and the growth of bacteria and yeast. It is used to induce apoptosis.
Biochem/physiol Actions:	K⁺-selective ionophoric cyclodepsipeptide; potassium ionophore which uncouples oxidative phosphorylation, induces apoptosis in murine thymocytes, inhibits NGF-induced neuronal differentiation and antagonizes ET-induced vasoconstriction.
Biochem/physiol Actions:	Valinomycin is a K+-selective ionophoric cyclodepsipeptide. It is a potassium ionophore which uncouples oxidative phosphorylation, induces apoptosis in murine thymocytes, inhibits NGF-induced neuronal differentiation and antagonizes ET-induced vasoconstriction. It is reported to be insecticidal, nematicidal and antiviral.
General description:	Chemical structure: peptide
Other Notes:	Keep container tightly closed in a dry and well-ventilated place. Hygroscopic.
Packaging:	5 mL in glass bottle

Hazard Codes	Xn
Risk Statements	21/22
Safety Statements	36/37
RIDADR	UN 1993 / PGIII
WGK Germany	WGK 1
Flash Point(F)	188.6 °F - closed cup
Flash Point(C)	87 °C - closed cup

Purity	≥90% (HPLC)
Storage Temp.	2-8°C
UNSPSC	51101500

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