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VU0240551

SIGMA/V3890 - ≥98% (HPLC)

Synonym: CID 7211972; N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]-acetamide; SID 56405457; VU0240551-1; VU0240551-2-D4

CAS Number: 893990-34-6
Empirical Formula (Hill Notation): C16H14N4OS2
Molecular Weight: 342.44
MDL Number: MFCD05957363
Linear Formula: C16H14N4OS2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-V3890-5MG 5 mg
 $229.00
1/EA		 Add To Favorites
45-V3890-25MG 25 mg
 $0.00
1/EA
CALL FOR PRICE		 Add To Favorites

 

assay ≥98% (HPLC)
form powder
InChI 1S/C16H14N4OS2/c1-11-9-23-16(17-11)18-14(21)10-22-15-8-7-13(19-20-15)12-5-3-2-4-6-12/h2-9H,10H2,1H3,(H,17,18,21)
InChI key WJRWSLORVIHRNX-UHFFFAOYSA-N
Quality Level 100 
SMILES string Cc1csc(NC(=O)CSc2ccc(nn2)-c3ccccc3)n1
solubility DMSO: >20 mg/mL
storage temp. 2-8°C
Biochem/physiol Actions: VU0240551 is a potent, selective KCC2 inhibitor. KCC2 is a potassium-chloride exchanger expressed specifically in neurons. KCC2 functions to lower intracellular chloride concentrations below the electrochemical potential of the cells, thereby increasing the hyperexcitability of the neurons. KCC2 activity enhances GABA and other inhibitory neurotransmission and is implicated in pain processing. VU0240551 was discovered in a high-throughput screen, followed by directed medicinal chemistry. VU0240551 is selective for KCC2 over NKCC1. VU0240551 binds competitively to the K+ site and binds noncompetitively to the Cl- site. VU0240551 is the only small molecule with specificity for a KCC family member.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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