VU0238429

SIGMA/V4515 - solubility: ≥20 mg/mL in DMSO

Synonym: 1-[(4-Methoxyphenyl)methyl]-5-(trifluoromethoxy)-1H-indole-2,3-dione

CAS Number: 1160247-92-6
Empirical Formula (Hill Notation): C₁₇H₁₂F₃NO₄
Molecular Weight: 351.28
MDL Number: MFCD16618396
Linear Formula: C₁₇H₁₂F₃NO₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-V4515-5MG	5 mg	$80.50 1/EA		Add To Favorites
45-V4515-25MG	25 mg	$323.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	orange
form	powder
InChI	1S/C17H12F3NO4/c1-24-11-4-2-10(3-5-11)9-21-14-7-6-12(25-17(18,19)20)8-13(14)15(22)16(21)23/h2-8H,9H2,1H3
InChI key	CKLGZXFOLMHCMC-UHFFFAOYSA-N
Quality Level	100
SMILES string	COc1ccc(CN2C(=O)C(=O)c3cc(OC(F)(F)F)ccc23)cc1
solubility	DMSO: ≥20 mg/mL
storage temp.	2-8°C

Biochem/physiol Actions:	VU0238429 is a selective muscarinic acetylcholine receptor 5 (M5) positive allosteric modulator; causes leftward shift in acetylcholine potency. M5 is thought to regulate cerebral blood flow, and activation of M5 may be therapeutic for Alzheimer′s disease. VU0238429 is the first reported M5-selective small molecule of any kind. It is >30-fold more selective for M5 over M1, M2, M3, and M4.
Features and Benefits:	This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging:	5, 25 mg in glass bottle

Symbol	GHS07,GHS09
Signal word	Warning
Hazard statements	H319 - H400
Precautionary statements	P273 - P305 + P351 + P338
Hazard Codes	Xi,N
Risk Statements	36-50/53
Safety Statements	26-60-61
RIDADR	UN 3077 9 / PGIII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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