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VU0238429

SIGMA/V4515 - solubility: ≥20 mg/mL in DMSO

Synonym: 1-[(4-Methoxyphenyl)methyl]-5-(trifluoromethoxy)-1H-indole-2,3-dione

CAS Number: 1160247-92-6
Empirical Formula (Hill Notation): C17H12F3NO4
Molecular Weight: 351.28
MDL Number: MFCD16618396
Linear Formula: C17H12F3NO4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-V4515-5MG 5 mg
 $75.50
1/EA		 Add To Favorites
45-V4515-25MG 25 mg
 $302.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color orange
form powder
InChI 1S/C17H12F3NO4/c1-24-11-4-2-10(3-5-11)9-21-14-7-6-12(25-17(18,19)20)8-13(14)15(22)16(21)23/h2-8H,9H2,1H3
InChI key CKLGZXFOLMHCMC-UHFFFAOYSA-N
Quality Level 100 
SMILES string COc1ccc(CN2C(=O)C(=O)c3cc(OC(F)(F)F)ccc23)cc1
solubility DMSO: ≥20 mg/mL
storage temp. 2-8°C
Biochem/physiol Actions: VU0238429 is a selective muscarinic acetylcholine receptor 5 (M5) positive allosteric modulator; causes leftward shift in acetylcholine potency.
Biochem/physiol Actions: VU0238429 is a selective muscarinic acetylcholine receptor 5 (M5) positive allosteric modulator; causes leftward shift in acetylcholine potency. M5 is thought to regulate cerebral blood flow, and activation of M5 may be therapeutic for Alzheimer′s disease. VU0238429 is the first reported M5-selective small molecule of any kind. It is >30-fold more selective for M5 over M1, M2, M3, and M4.
Features and Benefits: This compound is featured on the Acetylcholine Receptors (Muscarinic)  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 25 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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