VU0357017 monohydrochloride
SIGMA/V4640 - ≥98% (HPLC)
Synonym: 4-
CAS Number: 1135242-13-5
Empirical Formula (Hill Notation): C18H27N3O3 · HCl
Molecular Weight: 369.89
MDL Number: MFCD17215959
Linear Formula: C18H27N3O3 · HCl
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to off-white |
form | powder |
InChI | 1S/C18H27N3O3.ClH/c1-3-24 |
InChI key | XKJQVUIXSBOCPP-UHFFFAOYSA |
Quality Level | 100 |
SMILES string | Cl.CCOC(=O)N1CCC(CC1)NCCN |
solubility | DMSO: ≥10 mg/mL |
storage temp. | 2-8°C |
Biochem/physiol Actions: | VU0357017 is a subtype-selective M1 muscarinic acetylcholine allosteric agonist. VU0357017 has a potency of 200 nM and Achmax of 81% and had no activity at M2-M5 up to the highest concentrations tested and also had little or no detectable antagonist activity at any other mAChR subtype at concentrations over 2 orders of magnitude higher than those required to activate M1 or activity at a large panel of GPCRs, ion channels, and transporters. In contrast, TBPB inhibited responses to ACh at each of the other mAChR subtypes. VU0357017 was active in reversing cognitive deficits induced by scopolamine in a preclinical rodent model. |
Features and Benefits: | This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
Packaging: | 5, 25 mg in glass bottle |
Hazard Codes | N |
Risk Statements | 52/53 |
Safety Statements | 61 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 2 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |