Monoclonal Anti-Vascular Endothelial Growth Factor antibody produced in mouse
SIGMA/V4758 - clone 26503, purified immunoglobulin, lyophilized powder
Synonym: Anti-VEGF
MDL Number: MFCD00282511
Product Type: Chemical
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | 26503, monoclonal |
| conjugate | unconjugated |
| form | lyophilized powder |
| isotype | IgG2b |
| Quality Level | 200  |
| species reactivity | primate, human |
| storage temp. | −20°C |
| technique(s) | capture ELISA: 2-8 μg/mL |
| neutralization: suitable | |
| western blot: 1-2 μg/mL | |
| UniProt accession no. | P15692  |
| Application: | Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below. Western Blotting (1 paper) |
| Application: | Monoclonal Anti-Vascular Endothelial Growth Factor antibody produced in mouse was used to block the interaction between VEGF and kinase domain receptor in Calf Pulmonary Aortic Endothelial (CPAE) cells. |
| Biochem/physiol Actions: | The vascular endothelial growth factor family consists of five members, VEGF-A to VEGF-E. They play important roles in important role in embryonic vasculogenesis, angiogenesis and homeostasis. The interaction between VEGFs and their respective receptors results in the activation of MAPK, PI3K, PKC, FAK and Src kinase pathways. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | The antibody will neutralize the biological activity of recombinant human VEGF165. It also recognizes VEGF121. |
| Immunogen: | purified recombinant Sf21-derived human VEGF (165 aa isoform). |
| Physical form: | Lyophilized from a 0.2 μm solution in phosphate buffered saline containing carbohydrates. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 51111800 |