Verrucarin A from Myrothecium sp.
SIGMA/V4877 - ≥85.0% (HPLC)
Synonym: Muconomycin A
CAS Number: 3148-09-2
Empirical Formula (Hill Notation): C27H34O9
Molecular Weight: 502.55
MDL Number: MFCD00056759
Linear Formula: C27H34O9
Product Type: Chemical
| assay | ≥85.0% (HPLC) |
| InChI | 1S/C27H34O9/c1-16-8-10-26 |
| InChI key | NLUGUZJQJYVUHS-YDFGWWAZSA |
| Quality Level | 200  |
| SMILES string | CC1CCOC(=O)C=CC=CC(=O) |
| storage temp. | −20°C |
| Application: | Verrucarin A from Myrothecium sp has been used: • as a translation initiation inhibitor in P. falciparum W2 strain • as a peptidyl transfer inhibitor to test sensitivity in methyltransferase knock-out S. cerevisiae cells • to test its cytotoxicity in renal cell carcinoma cells |
| Biochem/physiol Actions: | Verrucarin A binds to the P and A sites in ribosomes and blocks peptide-bond and translation initiation. It inhibits the clear cell renal cell carcinoma (CCRCC) proliferation. Verrucarin A blocks the peptidyl transferase activity and favors apoptosis induction in cancer cells |
| Biochem/physiol Actions: | Verrucarin A is phytotoxic to plantlet cultures and cytotoxic to cultured mammalian cell lines. |
| General description: | Verrucarin derived from the Myrothecium verrucari, a fungal plant pathogen is a macrocyclic trichothecene compound. |
| Other Notes: | Macrocyclic trichothecene mycotoxin. |
| Symbol |  GHS06 |
| Signal word | Danger |
| Hazard statements | H300 + H310 + H330 |
| Precautionary statements | P260 - P264 - P280 - P284 - P301 + P310 - P302 + P350 |
| Hazard Codes | T+ |
| Risk Statements | 26/27/28 |
| Safety Statements | 22-36/37/39-45 |
| RIDADR | UN 3462 6.1 / PGI |
| WGK Germany | WGK 3 |
| Purity | ≥85.0% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |