Veratridine
SIGMA/V5754 - ≥90% (HPLC), powder
Synonym: 3-
CAS Number: 71-62-5
Empirical Formula (Hill Notation): C36H51NO11
Molecular Weight: 673.79
EC Number: 200-758-4
MDL Number: MFCD00082515
Linear Formula: C36H51NO11
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: V5754-100MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: V5754-25MG
| assay | ≥90% (HPLC) |
| color | white to off-white |
| form | powder |
| InChI | 1S/C36H51NO11/c1-19-6-11- |
| InChI key | FVECELJHCSPHKY-FCSYLLAHSA |
| Quality Level | 100  |
| SMILES string | COc1ccc(cc1OC)C(=O)OC2CC[ |
| solubility | ethanol: 50 mg/mL |
| storage temp. | −20°C |
| Application: | Veratridine has been used: • to record the veratridine-dependent increase in the late Na+ current using a HEK293 cell line stably transfected with human Na v1.5 24(4) to measure the ranolazine-induced inhibition of basal and veratridine-activated I Na late • to assess the effects of veratridine on action potentials (APs) in hiPSC-cardiomyocyte preparations externally paced in current-clamp mode • to study the inhibitory effects of veratridine on hERG1 current in stably transfected HEK293 cells • to treat neuroblastoma 2-a cells to improve sensitivity for N2a assay |
| Biochem/physiol Actions: | Opens voltage-dependent Na+ channels and prevents their inactivation. This, in turn, opens voltage-activated calcium channels, thus increasing intracellular calcium content and inducing neurotransmitter release. Alkaloid neurotoxin which depolarizes excitable tissue; used to increase membrane sodium permeability. Veratridine is cytotoxic to chromaffin cells in vitro. |
| Biochem/physiol Actions: | Veratridine has been used as an insecticide, acting as a paralytic agent with higher toxicity to insects than to mammals. |
| General description: | Veratridine is one of several alkaloids isolated from the seeds of Schoenocaulon officinale and from the rhizome of Veratrum album. The crude extract is called veratrine or sabadilla and contains cevadine, veratridine, cevadilline, sabadine and cevine. It is a neurotoxin, which belongs to the family Liliaceae and genus, Schoenocaulon. Veratridine is soluble in lipid. |
| Packaging: | 10 mg in glass insert |
| Packaging: | 25, 100 mg in glass bottle |
| Symbol |   GHS06,GHS08 |
| Signal word | Danger |
| Hazard statements | H300 + H310 + H330 - H315 - H319 - H335 - H361f - H373 - H412 |
| Precautionary statements | P201 - P262 - P280 - P301 + P310 + P330 - P302 + P352 + P310 - P304 + P340 + P310 |
| Hazard Codes | T+ |
| Risk Statements | 26/27/28-36/37/38-48/20-52/53-62 |
| Safety Statements | 26-28-36/37-45-61 |
| RIDADR | UN 1544PSN1 6.1 / PGI |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥90% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |