Vincristine sulfate salt

SIGMA/V8879 - 95.0-105.0% (HPLC), powder or crystals

Synonym: 22-Oxovincaleukoblastine sulfate salt; Leurocristine sulfate salt; VCR

CAS Number: 2068-78-2
Empirical Formula (Hill Notation): C₄₆H₅₆N₄O₁₀ · H₂SO₄
Molecular Weight: 923.04
EC Number: 218-190-0
MDL Number: MFCD00084729
Linear Formula: C₄₆H₅₆N₄O₁₀ · H₂SO₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-V8879-1MG	1 mg	$122.00 1/EA	Add To Favorites
45-V8879-5MG	5 mg	$255.00 1/EA	Add To Favorites
45-V8879-25MG	25 mg	$1040.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: V8879-1MG

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	neoplastics
assay	95.0-105.0% (HPLC)
biological source	Streptomyces roseosporus
color	white to light yellow
form	powder or crystals
InChI	1S/C46H56N4O10.H2O4S/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6;1-5(2,3)4/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3;(H2,1,2,3,4)/t28-,37-,38+,39+,42-,43+,44+,45-,46-;/m0./s1
InChI key	AQTQHPDCURKLKT-PNYVAJAMSA-N
mode of action	protein synthesis \| interferes
Quality Level	200
SMILES string	OS(O)(=O)=O.CC[C@]1(O)CC2CN(CCc3c([nH]c4ccccc34)[C@@](C2)(C(=O)OC)c5cc6c(cc5OC)N(C=O)C7[C@](O)([C@H](OC(C)=O)[C@]8(CC)C=CCN9CC[C@]67C89)C(=O)OC)C1
storage condition	(Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)
storage temp.	−20°C

Analysis Note:	Freely soluble in water, Soluble in methanol, slightly soluble in ethanol
Application:	Vincristine is an antitumor alkaloid isolated from Vinca Rosea. It is used to treat acute leukaemia, malignant lymphoma, Hodgkin′s disease, acute erythraemia, acute panmyelosis, breast cancer, Kaposi’s sarcoma and testicular cancer. Vincristine is widely used in cancer research. It is used to study multi-drug resistance. It is used to inhibit cell cycle progression at M-phase and to inhibit monoamine oxidase (MAO) .
Biochem/physiol Actions:	Vincristine is a plant alkaloid that inhibits microtubule assembly by binding tubulin and inducing coiled spiral aggregate formation. It arrests cell cycle in G2/M-phase by blocking mitotic spindle formation. Vincristine triggers Raf-1 activation, phosphorylation of bcl-2-family proteins, induction of p53 expression, and apoptosis in several tumor cell lines. It inhibits VEGF production in leukemia cell lines. It is a substrate for Pgp and CYP3A4. MRP1 transports vincristine in an ATP- and GSH-dependent manner. Vincristine has some immunosuppressant effect. Vincristine may also interfere with amino acid, cyclic AMP, and glutathione metabolism, calmodulin-dependent Ca2+-transport, cellular respiration, and nucleic acid and lipid biosynthesis.
Other Notes:	Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.
Packaging:	1, 5, 25 mg in glass bottle

Symbol	GHS06,GHS08
Signal word	Danger
Hazard statements	H300 - H341 - H361fd
Precautionary statements	P201 - P301 + P310 + P330
Hazard Codes	T
Risk Statements	63-25-62-68
Safety Statements	36/37-45
RIDADR	UN 2811 6.1 / PGII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	95.0-105.0% (HPLC)
Storage Temp.	−20°C
UNSPSC	51101500

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