WS-12
SIGMA/W0519 - ≥98% (HPLC), powder
Synonym: (1R,2S,5R)
CAS Number: 68489-09-8
Empirical Formula (Hill Notation): C18H27NO2
Molecular Weight: 289.41
MDL Number: MFCD11100191
Linear Formula: C18H27NO2
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to off-white |
form | powder |
InChI | 1S/C18H27NO2/c1-12(2)16-1 |
InChI key | HNSGVPAAXJJOPQ-NVPAJSRCSA |
Quality Level | 100 ![]() |
SMILES string | COc1ccc(NC(=O)C2C[C@H](C) |
solubility | DMSO: >20 mg/mL |
storage temp. | −20°C |
Biochem/physiol Actions: | WS-12 is a high-affinity, selective TRPM8 (cold menthol receptor 1; CMR1) agonist. TRPM8 agonists induce a cooling sensation in sensory neurons and produce profound, mechanistically novel analgesia in chronic pain states such as neuropathic pain. |
Biochem/physiol Actions: | WS-12 is a menthol derivative, that shows a specific binding affinity towards TRPM8 (transient receptor potential cation channel subfamily M member 8) receptor. TRPM8 is associated with prostate cancer and thus, WS-12 might be useful in reducing the progression of cancer. |
Packaging: | 5 mg in glass bottle |
Symbol | ![]() |
Signal word | Warning |
Hazard statements | H410 |
Precautionary statements | P273 |
Hazard Codes | N |
Risk Statements | 50 |
Safety Statements | 53-61 |
RIDADR | UN 3077 9 / PGIII |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |