Wogonin hydrate
SIGMA/W0769 - ≥98% (HPLC), solid
Synonym: 5,7-
CAS Number: 632-85-9 (anhydrous)
Empirical Formula (Hill Notation): C16H12O5 · xH2O
Molecular Weight: 284.26 (anhydrous basis)
MDL Number: MFCD12828871
Linear Formula: C16H12O5 · xH2O
Product Type: Chemical
| assay | ≥98% (HPLC) |
| form | solid |
| InChI | 1S/C16H12O5.H2O/c1-20-15- |
| InChI key | XLCSETHCROERAU-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | O.COc1c(O)cc(O)c2C(=O)C=C |
| solubility | DMSO: ≥20 mg/mL |
| storage temp. | 2-8°C |
| Application: | Wogonin hydrate has been used to enhance the cytotoxicity of oxaliplatin in gastric cancer cells and zebrafish xenograft model and to test its effect on the expression and secretion of adiponectin in mature 3T3-L1 adipocytes. |
| Biochem/physiol Actions: | Wogonin co-treatment enhances apoptosis and antitumor potential of chemotherapeutic drug, oxaliplatin in gastric cancer cells. It also improves the efficacy of fluorouracil and paclitaxel. Wogonin anti-oxidative functionality may be useful in treating neurodegenerative and inflammatory diseases. |
| Biochem/physiol Actions: | Wogonin is an anti-inflammatory agent and COX-2 inhibitor, which inhibits the induction of both iNOS and COX-2. Wogonin inhibits COX-2 (IC50 = 46 μM) without affecting COX-1. Wogonin inhibits iNOS induction and thus inhibts activation-induced C6 glial cell death. Specifically, Wogonin inhibits NF-kappaB-mediated iNOS induction. |
| Features and Benefits: | This compound is featured on the Nitric Oxide Synthases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| General description: | Wogonin is a flavonoid component of Scutellaria baicalensis Georgi roots. |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |