Wortmannin

SIGMA/W1628 - from Penicillium funiculosum, ≥98% (HPLC and TLC)

Synonym: KY 12420

CAS Number: 19545-26-7
Empirical Formula (Hill Notation): C₂₃H₂₄O₈
Molecular Weight: 428.43
MDL Number: MFCD00133927
Linear Formula: C₂₃H₂₄O₈
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-W1628-1MG	1 mg	$115.00 1/EA		Add To Favorites
45-W1628-5MG	5 mg	$377.00 1/EA		Add To Favorites
45-W1628-10MG	10 mg	$755.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC and TLC)
biological source	Penicillium funiculosum
color	off-white
form	powder
InChI	1S/C23H24O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-13,15H,5-7,9H2,1-4H3/t12-,13+,15+,22-,23-/m0/s1
InChI key	QDLHCMPXEPAAMD-QAIWCSMKSA-N
Quality Level	300
SMILES string	[H][C@@]12CCC(=O)[C@@]1(C)C[C@@H](OC(C)=O)C3=C2C(=O)c4occ5C(=O)O[C@H](COC)[C@@]3(C)c45
solubility	DMSO: soluble
	H₂O: unstable
storage temp.	2-8°C

Biochem/physiol Actions:	Wortmannin is a potent and specific phosphatidylinositol 3-kinase (PI3-K) inhibitor with an IC₅₀ of 2-4 nM. Inhibition of PI3-K/Akt signal transduction cascade enhances the apoptotic effects of radiation or serum withdrawal and blocks the antiapoptotic effect of cytokines. Inhibition of PI3-K by wortmannin also blocks many of the short-term metabolic effects induced by insulin receptor activation.
Features and Benefits:	This compound is a featured product for Cyclic Nucleotide and Kinase Phosphatase Biology research. Discover more featured Cyclic Nucleotide and Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits:	This compound is featured on the G Proteins (Heterotrimeric) and Phosphoinositide Kinases pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging:	10 mg in serum bottle

Symbol	GHS06
Signal word	Danger
Hazard statements	H300 + H310 + H330
Precautionary statements	P262 - P280 - P301 + P310 + P330 - P302 + P352 + P310 - P304 + P340 + P310
Hazard Codes	T+
Risk Statements	26/27/28
Safety Statements	28-36/37-45
RIDADR	UN 3462 6.1 / PGI
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC and TLC)
Storage Temp.	2-8°C
UNSPSC	12352207

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