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Wortmannin

SIGMA/W1628 - from Penicillium funiculosum, ≥98% (HPLC and TLC)

Synonym: KY 12420

CAS Number: 19545-26-7
Empirical Formula (Hill Notation): C23H24O8
Molecular Weight: 428.43
MDL Number: MFCD00133927
Linear Formula: C23H24O8
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-W1628-1MG 1 mg
 $118.00
1/EA		 Add To Favorites
45-W1628-5MG 5 mg
 $388.00
1/EA		 Add To Favorites
45-W1628-10MG 10 mg
 $776.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC and TLC)
biological source Penicillium funiculosum
color off-white
form powder
InChI 1S/C23H24O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-13,15H,5-7,9H2,1-4H3/t12-,13+,15+,22-,23-/m0/s1
InChI key QDLHCMPXEPAAMD-QAIWCSMKSA-N
Quality Level 300 
SMILES string [H][C@@]12CCC(=O)[C@@]1(C)C[C@@H](OC(C)=O)C3=C2C(=O)c4occ5C(=O)O[C@H](COC)[C@@]3(C)c45
solubility DMSO: soluble
  H2O: unstable
storage temp. 2-8°C
Biochem/physiol Actions: Wortmannin is a potent and specific phosphatidylinositol 3-kinase (PI3-K) inhibitor with an IC50 of 2-4 nM.
Biochem/physiol Actions: Wortmannin is a potent and specific phosphatidylinositol 3-kinase (PI3-K) inhibitor with an IC50 of 2-4 nM. Inhibition of PI3-K/Akt signal transduction cascade enhances the apoptotic effects of radiation or serum withdrawal and blocks the antiapoptotic effect of cytokines. Inhibition of PI3-K by wortmannin also blocks many of the short-term metabolic effects induced by insulin receptor activation.
Features and Benefits: This compound is a featured product for Cyclic Nucleotide and Kinase Phosphatase Biology research. Discover more featured Cyclic Nucleotide  and Kinase Phosphatase Biology  products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound is featured on the G Proteins (Heterotrimeric)  and Phosphoinositide Kinases  pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 10 mg in serum bottle
Purity ≥98% (HPLC and TLC)
Storage Temp. 2-8°C
UNSPSC 12352207

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