WR-1065
SIGMA/W2020 - ≥98% (HPLC)
Synonym: 2-
CAS Number: 14653-77-1
Empirical Formula (Hill Notation): C5H14N2S · 2HCl
Molecular Weight: 207.16
MDL Number: MFCD00460339
Linear Formula: C5H14N2S · 2HCl
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to off-white |
| form | powder |
| InChI | 1S/C5H14N2S.2ClH/c6-2-1-3 |
| InChI key | XDRLRDHLCIFZIW-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | Cl.Cl.NCCCNCCS |
| solubility | H2O: ≥20 mg/mL |
| storage condition | desiccated |
| storage temp. | −20°C |
| Biochem/physiol Actions: | WR-1065 is cytoprotective cell-permeable reactive oxygen species scavenger and p53 activator and re-activator. Recently shown to have antiretroviral activity and an active metabolite of Amifostine which selectively protects normal tissues from the damaging effects of anti-neoplastic radiation therapy. |
| Biochem/physiol Actions: | WR-1065 is the active metabolite of the prodrug amifostine, generated by alkaline phosphatase. It is found to accumulate in many epithelial tissues. WR-1065 protects cellular membranes and DNA from free radical induced damage. |
| Packaging: | 10, 50 mg in glass bottle |
| Symbol |   GHS05,GHS07 |
| Signal word | Danger |
| Hazard statements | H302 - H318 |
| Precautionary statements | P280 - P305 + P351 + P338 |
| Hazard Codes | Xn |
| Risk Statements | 22-41 |
| Safety Statements | 26-39-41 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |