Wortmannin, Ready Made Solution
SIGMA/W3144 - from Penicillium funiculosum, ≥95% (HPLC)
Synonym: Antibiotic SL-2052
CAS Number: 19545-26-7
Empirical Formula (Hill Notation): C23H24O8
Molecular Weight: 428.43
Linear Formula: C23H24O8
Product Type: Chemical
| assay | ≥95% (HPLC) |
| biological source | Penicillium funiculosum |
| concentration | 10 mM in DMSO (0.2 μm filtered) |
| InChI | 1S/C23H24O8/c1-10(24)30-1 |
| InChI key | QDLHCMPXEPAAMD-QAIWCSMKSA |
| Quality Level | 200  |
| shipped in | wet ice |
| storage condition | protect from light |
| storage temp. | −20°C |
| Application: | Wortmannin, a low molecular weight membrane permeable hydrophobic fungal metabolite, is widely used to study and verify the involvement of phosphoinosidite 3-kinase (PI3K)/Akt in cell signaling cascades that regulate key processes such as cell survival and apoptosis. Wortmannin may also be used to block and study the functional roles of polo-like kinases involved in the regulation of mitosis. |
| Application: | Wortmannin, Ready Made Solution has been used: • as a phosphoinositide 3-kinase (PI3K) pathway inhibitor • as an endoderm-inducing agent in stem cell selection and differentiation • as a autophagy inhibitor |
| Biochem/physiol Actions: | Wortmannin is a low molecular weight; hydrophobic fungal metabolite with a sterol-like structure produced by Penicilium fumiculosum. Inhibition of PI3K/Akt signal transduction cascade by wortmannin, enhances the apoptotic effects of radiation or serum withdrawal and blocks the antiapoptotic effect of cytokines. PI3K inhibition by wortmannin also blocks many of the short-term metabolic effects induced by insulin receptor activation. Research has demonstrated that wortmannin inhibits two enzymes from mitotical division, key regulators Polo-like kinase (Plk) family, Plk1 and Plk3. |
| Biochem/physiol Actions: | Wortmannin is a low-molecular-weight hydrophobic fungal metabolite with a sterol-like structure produced by Penicillium funiculosum. It is a selective inhibitor of phosphoinosidite 3-kinase. It interferes with Akt signal transduction cascade, enhancing the apoptotic effects of radiation or serum withdrawal and blocks the antiapoptotic effect of cytokines. Wortmannin is membrane-permeable, thus facilitating whole-cell studies of G-protein-coupled receptor and receptor tyrosine kinase signalling pathways. PI3K inhibition by wortmannin also blocks many of the short-term metabolic effects induced by insulin receptor activation. Research has demonstrated that wortmannin inhibits two mitotic enzymes, key regulators in the Polo-like kinase (Plk) family, Plk1 and Plk3. |
| Biochem/physiol Actions: | Wortmannin possesses anti-inflammatory properties. This mold metabolite is capable of preventing an intermediate step in transcytosis. In fisher rat thyroid (FRT) cells, wortmannin helps to block bidirectional transcytosis of ricin. |
| Features and Benefits: | This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| Physical form: | Wortmannin Ready Made Solution supplied as a 10 mM 0.2 μm-filtered solution in DMSO. |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 + H332 |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22 |
| Safety Statements | 36/37 |
| RIDADR | NA 1993 / PGIII |
| WGK Germany | WGK 2 |
| Flash Point(F) | 188.6 °F - closed cup |
| Flash Point(C) | 87 °C - closed cup |
| Purity | ≥95% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |