Synonym: 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c][1]benzopyran-6-one; 7-Methoxy-5,11,12-trihydroxycoumestan
CAS Number: 524-12-9
Empirical Formula (Hill Notation): C16H10O7
Molecular Weight: 314.25
MDL Number: MFCD07778564
Linear Formula: C16H10O7
Product Type: Chemical
assay |
≥98% (HPLC) |
color |
white to brown |
form |
powder |
InChI |
1S/C16H10O7/c1-21-6-2-10(19)14-12(3-6)23-16(20)13-7-4-8(17)9(18)5-11(7)22-15(13)14/h2-5,17-19H,1H3 |
InChI key |
XQDCKJKKMFWXGB-UHFFFAOYSA-N |
Quality Level |
100 ![External link](https://krackeler.com/images/sigma/ext-link.gif) |
SMILES string |
COc1cc(O)c-2c(OC(=O)c3c-2oc4cc(O)c(O)cc34)c1 |
solubility |
DMSO: 10 mg/mL, clear |
storage temp. |
2-8°C |
Biochem/physiol Actions: |
Wedelolactone inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα. Irreversible inhibitor of IKKα and β kinase activity (IC50 < 10 μM). Wedelolactone has no effects on p38 MAP kinase or Akt. |
Other Notes: |
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. W4016.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin. ![External link](https://krackeler.com/images/sigma/ext-link.gif) |
Packaging: |
1 mg in glass bottle |
Hazard Codes |
Xn |
Risk Statements |
22-43 |
Safety Statements |
36/37 |
RIDADR |
NONH for all modes of transport |
WGK Germany |
WGK 3 |
Flash Point(F) |
Not applicable |
Flash Point(C) |
Not applicable |
Purity |
≥98% (HPLC) |
Storage Temp. |
2-8°C |
UNSPSC |
12352200 |