Synonym: 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c][1]benzopyran-6-one; 7-Methoxy-5,11,12-trihydroxycoumestan
CAS Number: 524-12-9
Empirical Formula (Hill Notation): C16H10O7
Molecular Weight: 314.25
MDL Number: MFCD07778564
Linear Formula: C16H10O7
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
white to brown |
| form |
powder |
| InChI |
1S/C16H10O7/c1-21-6-2-10(19)14-12(3-6)23-16(20)13-7-4-8(17)9(18)5-11(7)22-15(13)14/h2-5,17-19H,1H3 |
| InChI key |
XQDCKJKKMFWXGB-UHFFFAOYSA-N |
| Quality Level |
100  |
| SMILES string |
COc1cc(O)c-2c(OC(=O)c3c-2oc4cc(O)c(O)cc34)c1 |
| solubility |
DMSO: 10 mg/mL, clear |
| storage temp. |
2-8°C |
| Biochem/physiol Actions: |
Wedelolactone inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα. Irreversible inhibitor of IKKα and β kinase activity (IC50 < 10 μM). Wedelolactone has no effects on p38 MAP kinase or Akt. |
| Packaging: |
1 mg in glass bottle |
| Hazard Codes |
Xn |
| Risk Statements |
22-43 |
| Safety Statements |
36/37 |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
2-8°C |
| UNSPSC |
12352200 |
