Monoclonal Anti-CNR2 antibody produced in mouse
SIGMA/WH0001269M1 - clone 3C7, purified immunoglobulin, buffered aqueous solution
Synonym: Anti-CB2; Anti-CX5; Anti-cannabinoid receptor 2 (macrophage)
Product Type: Chemical
Immunofluorescence Immunofluorescence of monoclonal antibody to CNR2 on HeLa cell. [antibody concentration 10 μg/mL]
Western Blotting Western Blot analysis of CNR2 expression in transfected 293T cell line by CNR2 monoclonal antibody, clone 3C7. Lanes Lane 1: CNR2 transfected lysate (39.7 kDa). Lane 2: Non-transfected lysate.
Western Blotting QC Western Blot detection against Immunogen (32.12 kDa).
ELISA Detection limit for recombinant GST tagged CNR2 is 0.1 ng/mL as a capture antibody.
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | 3C7, monoclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| GenBank® accession no. | NM_001841.1   |
| isotype | IgG1κ |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| technique(s) | immunofluorescence: suitable |
| indirect ELISA: suitable | |
| western blot: 1-5 μg/mL | |
| UniProt accession no. | P34972 |
| Application: | Monoclonal Anti-CNR2 antibody produced in mouse has been used in western blot analysis. |
| Biochem/physiol Actions: | Cannabinoid receptor 2 (CNR2) plays a crucial role in mediating anti-inflammatory and anti-atherosclerotic effects in vivo. It is also involved in cancer, bone metabolism and pain perception. CNR2 might be implicated in selective cell–cell interaction. Mutations in the gene has been associated with trochanter and hip bone mineral density (BMD). |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Cannabinoid receptor 2 (CNR2) is encoded by the gene mapped to human chromosome 1p36.11. The encoded protein belongs to a novel cadherin-related multigene family. Members of this family contain six cadherin repeats and conserved DXNDNXPXF and DXD motifs with constitute putative calcium-binding sequences. |
| General description: | The cannabinoid delta-9-tetrahydrocannabi |
| Immunogen: | CNR2 (NP_001832.1, 302 a.a. ~ 360 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Sequence RSGEIRSSAHHCLAHWKKCVRGLGS |
| Legal Information: | GenBank is a registered trademark of United States Department of Health and Human Services |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |