Monoclonal Anti-GCN5L2 antibody produced in mouse
SIGMA/WH0002648M1 - clone 4D3, purified immunoglobulin, buffered aqueous solution
Synonym: Anti-GCN5; Anti-GCN5 general control of amino-acid synthesis 5-like 2 (yeast); Anti-MGC102791; Anti-hGCN5
MDL Number: MFCD03791929
Product Type: Chemical
antibody form | purified immunoglobulin |
antibody product type | primary antibodies |
biological source | mouse |
clone | 4D3, monoclonal |
conjugate | unconjugated |
form | buffered aqueous solution |
GenBank® accession no. | BC032743 ![]() ![]() |
isotype | IgG2bκ |
Quality Level | 100 ![]() |
shipped in | dry ice |
species reactivity | human |
storage temp. | −20°C |
technique(s) | immunofluorescence: suitable |
indirect ELISA: suitable | |
western blot: 1-5 μg/mL | |
UniProt accession no. | Q92830 ![]() ![]() |
Biochem/physiol Actions: | General control of amino acid synthesis protein 5-like2 (GCN5L2) regulates periodontitis through acetylation of dickkopf-related protein 1 (DKK1). It regulates early region 1A (E1A) dependant transactivation of human adenovirus. The protein modulates osteogenic differentiation of mesenchymal stem cells by blocking NF-κB (nuclear factor-κB) signalling pathway. GCN5 interacts with (origin recognition complex subunit 5) Orc5 and improves the chromatin-opening function of Orc5. |
Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
General description: | General control of amino acid synthesis protein 5-like2 (GCN5L2) also known as KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM]GCN5L2 gene is located on human chromosome 17q21.2. This protein is expressed in ovaries. |
Immunogen: | GCN5L2 (AAH32743, 738 a.a. ~ 837 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Sequence KNLLAQIKSHPSAWPFMEPVKKSEA |
Legal Information: | GenBank is a registered trademark of United States Department of Health and Human Services |
Physical form: | Solution in phosphate buffered saline, pH 7.4 |
RIDADR | NONH for all modes of transport |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Storage Temp. | −20°C |
UNSPSC | 12352203 |