Monoclonal Anti-HES1 antibody produced in mouse
SIGMA/WH0003280M1 - clone 4D9, purified immunoglobulin, buffered aqueous solution
Synonym: Anti-FLJ20408; Anti-HES1; Anti-HHL; Anti-HRY; Anti-hairy and enhancer of split 1, (Drosophila)
MDL Number: MFCD03096856
Product Type: Chemical
antibody form | purified immunoglobulin |
antibody product type | primary antibodies |
biological source | mouse |
clone | 4D9, monoclonal |
conjugate | unconjugated |
form | buffered aqueous solution |
GenBank® accession no. | NM_005524 |
isotype | IgG2bκ |
Quality Level | 100 |
shipped in | dry ice |
species reactivity | human |
storage temp. | −20°C |
technique(s) | indirect ELISA: suitable |
western blot: 1-5 μg/mL | |
UniProt accession no. | Q14469 |
Application: | Monoclonal Anti-HES1 antibody has been used in western blotting. |
Biochem/physiol Actions: | Hairy and enhancer of split-1 (HES1) is required for regulating NPC (neural progenitor cells) fate and fetal brain development. This gene also helps to maintain the undifferentiated and proliferative status of NPCs. Absence of HES1 is linked with poor prognosis in colorectal adenocarcinoma. |
Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
General description: | Hairy and enhancer of split-1 (HES1) is a transcriptional repressor. It is a member of the basic helix-loop-helix family of transcription factors. This gene is mapped to human chromosome 3q29. |
General description: | This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box. (provided by RefSeq) |
Immunogen: | HES1 (NP_005515, 36 a.a. ~ 142 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Sequence KSSKPIMEKRRRARINESLSQLKTL |
Legal Information: | GenBank is a registered trademark of United States Department of Health and Human Services |
Physical form: | Solution in phosphate buffered saline, pH 7.4 |
RIDADR | NONH for all modes of transport |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Storage Temp. | −20°C |
UNSPSC | 12352203 |