Monoclonal Anti-PROC antibody produced in mouse
SIGMA/WH0005624M1 - clone 3A10, purified immunoglobulin, buffered aqueous solution
Synonym: Anti-PROC1; Anti-protein C; Anti-protein C (inactivator of coagulation factors Va and VIIIa)
MDL Number: MFCD00162768
Product Type: Chemical
Western Blotting PROC monoclonal antibody, clone 3A10. Western Blot analysis of PROC expression in human liver.
Western Blotting Western Blot analysis of PROC expression in transfected 293T cell line by PROC monoclonal antibody, clone 3A10. Lanes Lane 1: PROC transfected lysate (Predicted MW: 52.1 kDa). Lane 2: Non-transfected lysate.
Western Blotting QC Western Blot detection against Immunogen (36.41 kDa).
Immunoprecipitation Immunoprecipitation of PROC transfected lysate using anti-PROC monoclonal antibody and Protein A Magnetic Bead , and immunoblotted with PROC rabbit polyclonal antibody.
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | 3A10, monoclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| GenBank® accession no. | BC034377   |
| isotype | IgG1κ |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| technique(s) | immunoprecipitation (IP): suitable |
| indirect ELISA: suitable | |
| western blot: 1-5 μg/mL | |
| UniProt accession no. | P04070 |
| General description: | The PROC gene encodes protein C (EC 3.4.21.69), a vitamin K-dependent plasma glycoprotein that is a key component of the anticoagulant system. Protein C is cleaved to its activated form, ′activated protein C′ (APC) on endothelial cells by the thrombin-thrombomodulin complex (MIM 176930; MIM 188040) and then acts as a serine protease to degrade the activated forms of coagulation factors V (F5; MIM 612309) and VIII (F8; see MIM 306700). Protein S (PROS1; MIM 176880), also a vitamin K-dependent plasma protein, functions as a cofactor to activated protein C.[supplied by OMIM |
| Immunogen: | PROC (AAH34377, 32 a.a. ~ 131 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Sequence RAHQVLRIRKRANSFLEELRHSSLE |
| Legal Information: | GenBank is a registered trademark of United States Department of Health and Human Services |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |