Monoclonal Anti-SNCG antibody produced in mouse
SIGMA/WH0006623M1 - clone 2C3, purified immunoglobulin, buffered aqueous solution
Synonym: Anti-BCSG1; Anti-SR; Anti-synuclein, gamma (breast cancer-specific protein 1)
MDL Number: MFCD02097426
Product Type: Chemical
Western Blotting Western Blot analysis of SNCG expression in transfected 293T cell line by SNCG monoclonal antibody, clone 2C3. Lanes Lane 1: SNCG transfected lysate (13.3 kDa). Lane 2: Non-transfected lysate.
Western Blotting SNCG monoclonal antibody, clone 2C3. Western Blot analysis of SNCG expression in human spleen.
Western Blotting QC Western Blot detection against Immunogen (37.4 kDa).
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | 2C3, monoclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| GenBank accession no. | BC014098   |
| isotype | IgG2aκ |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | indirect ELISA: suitable |
| western blot: 1-5 μg/mL | |
| UniProt accession no. | O76070 |
| Application: | Monoclonal Anti-SNCG antibody produced in mouse has been used in western blotting. |
| Biochem/physiol Actions: | Synuclein gamma (SNCG) induces migration, invasion and metastasis of tumor cells. It promotes the migration of human breast adenocarcinoma cell line (MCF7) by activating extracellular-signal regulated kinase (Erk) pathway and disrupting cell-cell junctions. SNCG is associated with breast or ovarian cancer progression. Urine SNCG is used as a prognostic biomarker for bladder cancer. |
| General description: | Synuclein gamma (SNCG) gene encodes a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of neurodegenerative diseases. Mutations in this gene have also been associated with breast tumor development. (provided by RefSeq). Synuclein gamma (SNCG) is a breast cancer specific gene. SNCG is highly expressed in malignant cancer cells and neuronal cells. SNCG gene is located on human chromosome 10q23.2. SNCG is a member of the brain protein synuclein family. |
| Immunogen: | SNCG (AAH14098, 21 a.a. ~ 127 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Sequence KTKQGVTEAAEKTKEGVMYVGAKTK |
| Legal Information: | GenBank is a registered trademark of United States Department of Health and Human Services |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |