Monoclonal Anti-STX1A antibody produced in mouse
SIGMA/WH0006804M1 - clone 1F9-1C9, purified immunoglobulin, buffered aqueous solution
Synonym: Anti-HPC1; Anti-STX1; Anti-p351; Anti-syntaxin 1A (brain)
Product Type: Chemical
Immunoblotting Monoclonal Anti-STX1A, Cat. No. WH0006804M1 used at the antibody concentration: 1 ~ 5 μg/mL. Specific band of ~33 kDa using human colon lysate.
Immunoblotting Monoclonal Anti-STX1A, Cat. No. WH0006804M1 used at the antibody concentration: 1 ~ 5 μg/mL. Specific band of ~33 kDa using human colon lysate.
Immunoblotting Monoclonal Anti-STX1A, Cat. No. WH0006804M1 used at the antibody concentration: 1 μg/mL. Specific band of ~53.35 kDa using immunogen protein lysate.
Western Blotting QC Western Blot detection against Immunogen (53.35 kDa).
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | 1F9-1C9, monoclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| GenBank® accession no. | BC003011.1   |
| isotype | IgG1κ |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| technique(s) | indirect ELISA: suitable |
| western blot: 1-5 μg/mL | |
| UniProt accession no. | Q16623 |
| Biochem/physiol Actions: | Syntaxin 1A (STX1A) which codes for constituent of the synaptic apparatus, plays a vital role in exocytosis of neurotransmitters from neuronal cells. Hemizygous deletions of STX1A is associated with neurological symptoms of Williams syndrome (WS). STX1A regulates expression of serotonin transporter (5-HTT) involved in maintaining serotonin level; therefore, decreased expression of the protein leads to irregularity in serotonergic neurotransmission, which is associated with autism. STX1A is expressed at low level in adenocarcinoma cells, but at high level in squamous cell lung carcinomas. It might have use in determining the prognosis of lung cancer survival and initial-stage non-small-cell lung cancer (NSCLC). |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Synaptic vesicles store neurotransmitters that are released during calcium-regulated exocytosis. The specificity of neurotransmitter release requires the localization of both synaptic vesicles and calcium channels to the presynaptic active zone. Syntaxins function in this vesicle fusion process. Syntaxins also serve as a substrate for botulinum neurotoxin type C, a metalloprotease that blocks exocytosis and has high affinity for a molecular complex that includes the alpha-latrotoxin receptor (MIM 600565) which produces explosive exocytosis (Zhang et al., 1995 [PubMed 7622072]).[supplied by OMIM |
| Immunogen: | STX1A (AAH03011.1, 1 a.a. ~ 251 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Sequence MKDRTQELRTAKDSDDDDDVAVTVD |
| Legal Information: | GenBank is a registered trademark of United States Department of Health and Human Services |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |