Monoclonal Anti-TYK2 antibody produced in mouse
SIGMA/WH0007297M1 - clone 6G12, purified immunoglobulin, buffered aqueous solution
Synonym: Anti-JTK1; Anti-tyrosine kinase 2
MDL Number: MFCD01634345
Product Type: Chemical
antibody form | purified immunoglobulin |
antibody product type | primary antibodies |
biological source | mouse |
clone | 6G12, monoclonal |
conjugate | unconjugated |
form | buffered aqueous solution |
GenBank accession no. | BC014243 |
isotype | IgG2aκ |
Quality Level | 100 |
shipped in | dry ice |
species reactivity | human |
storage temp. | −20°C |
target post-translational modification | unmodified |
technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable |
immunoprecipitation (IP): suitable | |
indirect ELISA: suitable | |
indirect immunofluorescence: suitable | |
western blot: 1-5 μg/mL | |
UniProt accession no. | P29597 |
Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
General description: | This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. (provided by RefSeq) |
Immunogen: | TYK2 (AAH14243, 276 a.a. ~ 375 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Sequence PVCHLRLLAQAEGEPCYIRDSGVAP |
Legal Information: | GenBank is a registered trademark of United States Department of Health and Human Services |
Physical form: | Solution in phosphate buffered saline, pH 7.4 |
RIDADR | NONH for all modes of transport |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Storage Temp. | −20°C |
UNSPSC | 12352203 |