Monoclonal Anti-ADAMTS4 antibody produced in mouse
SIGMA/WH0009507M1 - clone 2A6, purified immunoglobulin, buffered aqueous solution
Synonym: Anti-ADAM metallopeptidase with thrombospondin type 1 motif, 4; Anti-ADAMTS2; Anti-ADAMTS4; Anti-ADMP1; Anti-KIAA0688
Product Type: Chemical
Immunoprecipitation Immunoprecipitation of ADAMTS4 transfected lysate using anti-ADAMTS4 monoclonal antibody and Protein A Magnetic Bead , and immunoblotted with ADAMTS4 rabbit polyclonal antibody.
ELISA Detection limit for recombinant GST tagged ADAMTS4 is 0.3 ng/mL as a capture antibody.
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | 2A6, monoclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| GenBank® accession no. | BC063293   |
| isotype | IgG1κ |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| technique(s) | immunoprecipitation (IP): suitable |
| indirect ELISA: suitable | |
| UniProt accession no. | O75173 |
| General description: | This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma. (provided by RefSeq) |
| Immunogen: | ADAMTS4 (AAH63293, 693 a.a. ~ 802 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Sequence RKFRYGYNNVVTIPAGATHILVRQQ |
| Legal Information: | GenBank is a registered trademark of United States Department of Health and Human Services |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |