Monoclonal Anti-SLK antibody produced in mouse
SIGMA/WH0009748M1 - clone 3E9, purified immunoglobulin, buffered aqueous solution
Synonym: Anti-KIAA0204; Anti-STE20-like kinase (yeast); Anti-STK2; Anti-bA16H23.1; Anti-se209
Product Type: Chemical
Immunohistochemistry Immunoperoxidase of monoclonal antibody to SLK on formalin-fixed paraffin-embedded human placenta. [antibody concentration 3 μg/mL]
Western Blotting SLK monoclonal antibody, clone 3E9 Western Blot analysis of SLK expression in HeLa S3 NE.
Western Blotting QC Western Blot detection against Immunogen (37.84 kDa).
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | 3E9, monoclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| GenBank® accession no. | NM_014720   |
| isotype | IgG1κ |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable |
| indirect ELISA: suitable | |
| western blot: 1-5 μg/mL | |
| UniProt accession no. | Q9H2G2 |
| Biochem/physiol Actions: | STE20 like kinase (SLK) is a modulator of cell motility. It phosphorylates cytoskeleton-bound proteins, which take part in the remodeling of migratory cell architecture. SLK is also involved in mitogen-activated protein kinase pathways. It acts as an activator of Jun N-terminal kinase (JNK) and transactivates tumor suppressor p53. |
| General description: | STE20 like kinase (SLK) is a 1204 amino acid serine/threonine kinase. It possesses a kinase domain located at the amino-terminal and a C-terminal regulatory domain with coiled-coils. SLK is group V germinal center kinase that is expressed in the nucleus, cytosol, microtubules and centrosomes. The SLK gene is localized on human chromosome 10q24.33. |
| Immunogen: | SLK (NP_055535, 1126 a.a. ~ 1235 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Sequence KHENQMRDLQLQCEANVRELHQLQN |
| Legal Information: | GenBank is a registered trademark of United States Department of Health and Human Services |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |