Monoclonal Anti-MVP antibody produced in mouse
SIGMA/WH0009961M1 - clone 2H3-1A6, purified immunoglobulin, buffered aqueous solution
Synonym: Anti-LRP; Anti-VAULT1; Anti-major vault protein
MDL Number: MFCD01633598
Product Type: Chemical
Immunohistochemistry Immunoperoxidase of monoclonal antibody to MVP on formalin-fixed paraffin-embedded human lung, adenosquamous cell carcinoma. [antibody concentration 3 μg/mL]
Immunofluorescence Immunofluorescence of monoclonal antibody to MVP on HeLa cell. [antibody concentration 10 μg/mL]
Western Blotting MVP monoclonal antibody, clone 2H3-1A6 Western Blot analysis of MVP expression in HeLa S3 NE.
Western Blotting QC Western Blot detection against Immunogen (123.97 kDa).
ELISA Detection limit for recombinant GST tagged MVP is approximately 1 ng/mL as a capture antibody.
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | 2H3-1A6, monoclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| GenBank® accession no. | BC015623   |
| isotype | IgG2aκ |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable |
| indirect ELISA: suitable | |
| indirect immunofluorescence: suitable | |
| western blot: 1-5 μg/mL | |
| UniProt accession no. | Q14764 |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | This gene encodes the major vault protein which is a lung resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences; however, the open reading frames are the same in both transcripts. (provided by RefSeq) |
| Immunogen: | MVP (AAH15623, 1 a.a. ~ 893 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Sequence MATEEFIIRIPPYHYIHVLDQNSNV |
| Legal Information: | GenBank is a registered trademark of United States Department of Health and Human Services |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |