Monoclonal Anti-HPSE antibody produced in mouse
SIGMA/WH0010855M5 - clone 4D7, purified immunoglobulin, buffered aqueous solution
Synonym: Anti-HPA; Anti-HPR1; Anti-HPSE1; Anti-HSE1; Anti-heparanase
MDL Number: MFCD04118468
Product Type: Chemical
Western Blotting QC Western Blot detection against Immunogen (36.63 kDa).
ELISA Detection limit for recombinant GST tagged HPSE is approximately 0.3 ng/mL as a capture antibody.
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | 4D7, monoclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| GenBank® accession no. | NM_006665   |
| isotype | IgG2bκ |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| technique(s) | indirect ELISA: suitable |
| western blot: 1-5 μg/mL | |
| UniProt accession no. | Q9Y251 |
| Biochem/physiol Actions: | The heparanase gene (HPSE/HPA) helps in the degeneration of heparan chains (HS). It controls the structure and activities of heparan sulfate proteoglycan (HSPG). This gene participates in the differentiation and development of prostate epithelial cells. HPA play a major role in cervical cancer metastasis and angiogenesis. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | The heparanase gene (HPSE) is a member of the Ets gene family. It is expressed in cytotrophoblasts, endothelial cells, keratinocytes, mast cells and hematopoietic cells like platelets, neutrophils, macrophages, T and B lymphocytes. HPSE gene is located on human chromosome 4q21. |
| Immunogen: | HPSE (NP_006656.1, 72 a.a. ~ 170 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Sequence LILLGSPKLRTLARGLSPAYLRFGG |
| Legal Information: | GenBank is a registered trademark of United States Department of Health and Human Services |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |