Monoclonal Anti-NCOA6 antibody produced in mouse
SIGMA/WH0023054M1 - clone 2D7, purified immunoglobulin, buffered aqueous solution
Synonym: Anti-AIB3; Anti-ASC2; Anti-KIAA0181; Anti-NRC; Anti-PRIP; Anti-RAP250; Anti-TRBP; Anti-nuclear receptor coactivator 6
MDL Number: MFCD08705573
Product Type: Chemical
Immunofluorescence Immunofluorescence of monoclonal antibody to NCOA6 on HeLa cell. [antibody concentration 10 μg/mL]
Western Blotting NCOA6 monoclonal antibody, clone 2D7 Western Blot analysis of NCOA6 expression in HeLa S3 NE.
Western Blotting QC Western Blot detection against Immunogen (37.84 kDa).
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | 2D7, monoclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| GenBank accession no. | NM_014071   |
| isotype | IgG2aκ |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | indirect ELISA: suitable |
| indirect immunofluorescence: suitable | |
| western blot: 1-5 μg/mL | |
| UniProt accession no. | Q14686 |
| Biochem/physiol Actions: | NCOA6 (Nuclear receptor coactivator 6) interacts with nuclear receptors in ligand-dependent or ligand-enhanced dependent manner to regulate nuclear receptor-mediated mammalian gene expression. The activation domain helps to increase the transcriptional activity of several nuclear receptors. It forms a dimer by binding to the liganded receptors, which lead to a structural change in NRC activation. It has also been reported that NCOA6 highly influences the binding of CREB-binding protein (CBP) during transcriptional activity of nuclear hormone receptors. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors. The encoded protein may also act as a general coactivator since it has been shown to interact with some basal transcription factors, histone acetyltransferases, and methyltransferases. (provided by RefSeq) |
| Immunogen: | NCOA6 (NP_054790, 1954 a.a. ~ 2063 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Sequence VGSHPELLPSIAPSQNLVSKETSTT |
| Legal Information: | GenBank is a registered trademark of United States Department of Health and Human Services |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |