Monoclonal Anti-DNAI1 antibody produced in mouse
SIGMA/WH0027019M1 - clone 2D10-2A5, purified immunoglobulin, buffered aqueous solution
Synonym: Anti-CILD1; Anti-ICS; Anti-MGC26204; Anti-PCD; Anti-dynein, axonemal, intermediate polypeptide 1
Product Type: Chemical
Immunoblotting Monoclonal Anti-DNAI1, Cat. No. WH0027019M1 used at the antibody concentration: 1 μg/mL. Specific band of ~102.63 kDa using immunogen protein lysate.
Western Blotting QC Western Blot detection against Immunogen (102.63 kDa).
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | 2D10-2A5, monoclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| GenBank accession no. | BC030583   |
| isotype | IgG2aκ |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | indirect ELISA: suitable |
| western blot: 1-5 μg/mL | |
| UniProt accession no. | Q9UI46 |
| Biochem/physiol Actions: | DNAI1 (Dynein axonemal intermediate chain 1) encodes an intermediate of outer dynein arms (ODA) proteins of cilia. Mutation in DNAI1 gene causes a trilogy syndrome named as Kartagener syndrome (KS), a rare recessive hereditary disorder named primary ciliary dyskinesia (PCD). |
| General description: | The inner- and outer-arm dyneins, which bridge between the doublet microtubules in axonemes, are the force-generating proteins responsible for the sliding movement in axonemes. The intermediate and light chains, thought to form the base of the dynein arm, help mediate attachment and may also participate in regulating dynein activity. This gene encodes an intermediate chain dynein, belonging to the large family of motor proteins. Mutations in this gene result in abnormal ciliary ultrastructure and function associated with primary ciliary dyskinesia (PCD) and Kartagener syndrome. (provided by RefSeq) |
| Immunogen: | DNAI1 (AAH30583, 1 a.a. ~ 699 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Sequence MIPASAKSPHKQPHKQSISIGRGTR |
| Legal Information: | GenBank is a registered trademark of United States Department of Health and Human Services |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |