Monoclonal Anti-GMNN antibody produced in mouse
SIGMA/WH0051053M1 - clone 1A8, purified immunoglobulin, buffered aqueous solution
Synonym: Anti-Gem; Anti-Geminin, DNA replication inhibitor
Product Type: Chemical
antibody form | purified immunoglobulin |
antibody product type | primary antibodies |
biological source | mouse |
clone | 1A8, monoclonal |
conjugate | unconjugated |
form | buffered aqueous solution |
GenBank® accession no. | BC005185 ![]() ![]() |
isotype | IgG1κ |
Quality Level | 100 ![]() |
shipped in | dry ice |
species reactivity | human |
storage temp. | −20°C |
technique(s) | immunofluorescence: suitable |
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable | |
indirect ELISA: suitable | |
western blot: 1-5 μg/mL | |
UniProt accession no. | O75496 ![]() ![]() |
Biochem/physiol Actions: | Geminin (GMNN) prevents replication of DNA. It participates in cancer pathophysiology and developmental process. This protein also participates in several stages of development like pre-implantation, germ layer formation, cell commitment and specification. It also has roles in the maintenance of genome integrity at mid blastula transition, epithelial to mesenchymal transition during gastrulation, neural development, organogenesis and axis patterning. GMNN controls chromatin remodeling. |
Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
General description: | Geminin (GMNN) is a nuclear regulator protein encoded by GMNN gene. This gene is located on human chromosome 6p22.3. It is expressed in the the cell cycle during S, G2 and M phases. |
Immunogen: | GMNN (AAH05185, 110 a.a. ~ 209 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Sequence LYEALKENEKLHKEIEQKDNEIARL |
Legal Information: | GenBank is a registered trademark of United States Department of Health and Human Services |
Physical form: | Solution in phosphate buffered saline, pH 7.4 |
RIDADR | NONH for all modes of transport |
WGK Germany | nwg |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Storage Temp. | −20°C |
UNSPSC | 12352203 |