Monoclonal Anti-FTS antibody produced in mouse
SIGMA/WH0064400M2 - clone 2A11, purified immunoglobulin, buffered aqueous solution
Synonym: Anti-FT1; Anti-fused toes homolog (mouse)
Product Type: Chemical
Western Blotting Western Blot analysis of FTS expression in transfected 293T cell line by FTS monoclonal antibody, clone 2A11. Lanes Lane 1: FTS transfected lysate (33.1 kDa). Lane 2: Non-transfected lysate.
Western Blotting QC Western Blot detection against Immunogen (57.86 kDa).
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | 2A11, monoclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| GenBank® accession no. | BC001134   |
| isotype | IgG1κ |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| technique(s) | indirect ELISA: suitable |
| western blot: 1-5 μg/mL | |
| UniProt accession no. | Q9H8T0 |
| Biochem/physiol Actions: | Fused toes homolog (FTS) interacts with the shelterin component telomeric repeat factor 1 (TRF1) and facilitates proper telomere replication. In addition, the protein also plays a vital role in regulation of protein kinase B/AKT signaling and vesicle trafficking. Deletion of the gene leads to general impairment of DNA synthesis and defective telomere replication. FTS control radioresistance of cervical cancer. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Fused toes homolog (FTS), also known as AKT interacting protein (AKTIP)/Ft1, is encoded by the gene mapped to human chromosome 16q12.2. Ft1 is a member of ubiquitin E2 variant (UEV) enzyme subfamily, characterized with a ubiquitin conjugation (UBC) domain lacking the catalytic cysteine involved in ubiquitin transfer. |
| General description: | The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB?s regulatory sites. Alternative splicing results in two transcript variants encoding the same protein. (provided by RefSeq) |
| Immunogen: | FTS (AAH01134, 1 a.a. ~ 292 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Sequence MNPFWSMSTSSVRKRSEGEEKTLTG |
| Legal Information: | GenBank is a registered trademark of United States Department of Health and Human Services |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |