Monoclonal Anti-PTPNS1 antibody produced in mouse
SIGMA/WH0140885M1 - clone 1D10, purified immunoglobulin, buffered aqueous solution
Synonym: Anti-BIT; Anti-CD172A; Anti-MFR; Anti-MYD1; Anti-P84; Anti-SHPS1; Anti-SIRP; Anti-SIRPALPHA1; Anti-SIRPalpha; Anti-SIRPalpha2; Anti-protein tyrosine phosphatase, non-receptor type substrate 1
MDL Number: MFCD01634182
Product Type: Chemical
Western Blotting SIRPA monoclonal antibody, clone 1D10 Western Blot analysis of SIRPA expression in IMR-32.
Western Blotting QC Western Blot detection against Immunogen (78.54 kDa).
ELISA Detection limit for recombinant GST tagged SIRPA is approximately 0.03 ng/mL as a capture antibody.
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | 1D10, monoclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| GenBank accession no. | BC026692   |
| isotype | IgG2aκ |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | rat, mouse, human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | indirect ELISA: suitable |
| western blot: 1-5 μg/mL | |
| UniProt accession no. | P78324 |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. (provided by RefSeq) |
| Immunogen: | SIRPA (AAH26692, 28 a.a. ~ 507 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Sequence VAGEEELQVIQPDKSVSVAAGESAI |
| Legal Information: | GenBank is a registered trademark of United States Department of Health and Human Services |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |