Monoclonal Anti-RNF168 antibody produced in mouse
SIGMA/WH0165918M1 - clone 3E1, purified immunoglobulin, buffered aqueous solution
Synonym: Anti-FLJ35794; Anti-ring finger protein 168
Product Type: Chemical
antibody form | purified immunoglobulin |
antibody product type | primary antibodies |
biological source | mouse |
clone | 3E1, monoclonal |
conjugate | unconjugated |
form | buffered aqueous solution |
GenBank® accession no. | NM_152617 ![]() ![]() |
isotype | IgG2bκ |
Quality Level | 100 ![]() |
shipped in | dry ice |
species reactivity | human, mouse, rat |
storage temp. | −20°C |
technique(s) | indirect ELISA: suitable |
indirect immunofluorescence: suitable | |
western blot: 1-5 μg/mL | |
UniProt accession no. | Q8IYW5 ![]() ![]() |
Biochem/physiol Actions: | Ring finger protein 168 (RNF168) associates with ubiquitinated histone H2A. It has an important role in the ubiquitination pathway and binds to the conjugated ubiquitin on damaged chromosomes. |
General description: | The complex repair response elicited by DNA double-strand breaks (DSBs) includes recruitment of several DNA repair proteins and ubiquitination of H2A-type histones (see MIM 142720). RNF168 is an E3 ubiquitin ligase critical for DSB repair (Stewart et al., 2009 [PubMed 19203578]).[supplied by OMIM |
Immunogen: | RNF168 (NP_689830, 462 a.a. ~ 571 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Sequence MVPNRQKGSPDEYHLRATSSPPDKV |
Legal Information: | GenBank is a registered trademark of United States Department of Health and Human Services |
Physical form: | Solution in phosphate buffered saline, pH 7.4 |
RIDADR | NONH for all modes of transport |
WGK Germany | nwg |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Storage Temp. | −20°C |
UNSPSC | 12352203 |