Monoclonal Anti-LNX2 antibody produced in mouse
SIGMA/WH0222484M1 - clone 4F7, purified immunoglobulin, buffered aqueous solution
Synonym: Anti-FLJ23932; Anti-MGC46315; Anti-PDZRN1; Anti-ligand of numb-protein X 2
Product Type: Chemical
antibody form | purified immunoglobulin |
antibody product type | primary antibodies |
biological source | mouse |
clone | 4F7, monoclonal |
conjugate | unconjugated |
form | buffered aqueous solution |
GenBank® accession no. | NM_153371 ![]() ![]() |
isotype | IgG2aκ |
Quality Level | 100 ![]() |
shipped in | dry ice |
species reactivity | human |
storage temp. | −20°C |
technique(s) | indirect ELISA: suitable |
western blot: 1-5 μg/mL | |
UniProt accession no. | Q8N448 ![]() ![]() |
Biochem/physiol Actions: | Ligand of numb-protein X 2 (LNX2) modulates NOTCH signaling and WNT/β-catenin pathway. It associates with junction adhesion molecule 4 (JAM 4) and has a role in epithelial-mesenchymal transition. LNX2 has been shown to be upregulated in ovarian cancer. |
General description: | Ligand of numb-protein X 2 (LNX2) is an E3 ubiquitin ligase and the gene encoding it is localized on chromosome 13q12.2. |
Immunogen: | LNX2 (NP_699202, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Sequence MGTTSDEMVSVEQTSSSSLNPLCFE |
Legal Information: | GenBank is a registered trademark of United States Department of Health and Human Services |
Physical form: | Solution in phosphate buffered saline, pH 7.4 |
RIDADR | NONH for all modes of transport |
WGK Germany | nwg |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Storage Temp. | −20°C |
UNSPSC | 12352203 |