Monoclonal Anti-FBXL22 antibody produced in mouse
SIGMA/WH0283807M1 - clone 1B6, purified immunoglobulin, buffered aqueous solution
Synonym: Anti-F-box and leucine-rich repeat protein 22; Anti-FLJ39626; Anti-Fbl22; Anti-MGC75496
Product Type: Chemical
antibody form | purified immunoglobulin |
antibody product type | primary antibodies |
biological source | mouse |
clone | 1B6, monoclonal |
conjugate | unconjugated |
form | buffered aqueous solution |
isotype | IgG2aκ |
Quality Level | 100 ![]() |
shipped in | dry ice |
species reactivity | human |
storage temp. | −20°C |
technique(s) | immunofluorescence: suitable |
indirect ELISA: suitable | |
UniProt accession no. | Q6P050 ![]() ![]() |
Biochem/physiol Actions: | F-box and leucine-rich repeat protein 22 (FBXL22) enhances the degradation of sarcomeric proteins and has a role in contraction of cardiac muscles. |
General description: | Members of the F-box protein family, such as FBXL22, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM |
Immunogen: | FBXL22 (NP_976307, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Sequence MHITQLNRECLLHLFSFLDKDSRKS |
Physical form: | Solution in phosphate buffered saline, pH 7.4 |
RIDADR | NONH for all modes of transport |
WGK Germany | nwg |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Storage Temp. | −20°C |
UNSPSC | 12352203 |