Monoclonal Anti-HES5 antibody produced in mouse
SIGMA/WH0388585M1 - clone 3C5, purified immunoglobulin, buffered aqueous solution
Synonym: Anti-hairy and enhancer of split 5 (Drosophila)
MDL Number: MFCD03096859
Product Type: Chemical
antibody form | purified immunoglobulin |
antibody product type | primary antibodies |
biological source | mouse |
clone | 3C5, monoclonal |
conjugate | unconjugated |
form | buffered aqueous solution |
GenBank® accession no. | NM_001010926 ![]() ![]() |
isotype | IgG2bκ |
Quality Level | 100 ![]() |
shipped in | dry ice |
species reactivity | human |
storage temp. | −20°C |
technique(s) | indirect ELISA: suitable |
western blot: 1-5 μg/mL | |
UniProt accession no. | Q5TA89 ![]() ![]() |
Biochem/physiol Actions: | Hes family bHLH transcription factor 5 (HES5) is a regulator of Wnt family member 3A (Wnt-3A) protein. It is involved in stimulating the proliferation and differentiation of hepatocellular carcinoma cells. Methylation of the HES5 promoter has been studied to have a link with prostate cancer. |
Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
General description: | This gene encodes a member of a family of basic helix-loop-helix transcriptional repressors. The protein product of this gene, which is activated downstream of the Notch pathway, regulates cell differentiation in multiple tissues. Disruptions in the normal expression of this gene have been associated with developmental diseases and cancer. (provided by RefSeq) |
Immunogen: | HES5 (NP_001010926, 28 a.a. ~ 121 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Sequence RRDRINSSIEQLKLLLEQEFARHQP |
Legal Information: | GenBank is a registered trademark of United States Department of Health and Human Services |
Physical form: | Solution in phosphate buffered saline, pH 7.4 |
RIDADR | NONH for all modes of transport |
WGK Germany | nwg |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Storage Temp. | −20°C |
UNSPSC | 12352203 |