Monoclonal Anti-BRCC2 antibody produced in mouse
SIGMA/WH0414899M5 - clone 3F4, purified immunoglobulin, buffered aqueous solution
Synonym: Anti-BRCC2
MDL Number: MFCD01321778
Product Type: Chemical
Immunofluorescence Immunofluorescence of monoclonal antibody to BLID on HeLa cell. [antibody concentration 10 μg/mL]
Western Blotting QC Western Blot detection against Immunogen (37.51 kDa).
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | 3F4, monoclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| GenBank accession no. | NM_001001786   |
| isotype | IgG2aκ |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunofluorescence: suitable |
| indirect ELISA: suitable | |
| western blot: 1-5 μg/mL | |
| UniProt accession no. | Q8IZY5 |
| Biochem/physiol Actions: | BRCC2 or BH3-like motif containing, cell death inducer acts as a tumor suppressor by modulating the AKT8 virus oncogene cellular homolog (Akt) pathway in breast cancer tissue. It associates with Bcl-2 long isoform (BCL-XL). BRCC2 also stimulates the caspase-dependent mitochondrial cell death pathway. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | This gene encodes a BH3-like motif containing protein involved in cell death. The encoded protein may induce apoptosis in a caspase-dependent manner. The protein is localized in both the cytoplasm and the mitochondrion. [SH |
| Immunogen: | BRCC2 (NP_001001786, 2 a.a. ~ 108 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Sequence VTLLPIEGQEVHFFEILESECVLYT |
| Legal Information: | GenBank is a registered trademark of United States Department of Health and Human Services |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |