XE-991

SIGMA/X2254 - ≥98% (HPLC)

Synonym: 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone

CAS Number: 122955-42-4
Empirical Formula (Hill Notation): C₂₆H₂₀N₂O
Molecular Weight: 376.45
MDL Number: MFCD05662331
Linear Formula: C₂₆H₂₀N₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-X2254-10MG	10 mg	$174.00 1/EA		Add To Favorites
45-X2254-50MG	50 mg	$738.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
InChI	1S/C26H20N2O/c29-25-21-5-1-3-7-23(21)26(17-19-9-13-27-14-10-19,18-20-11-15-28-16-12-20)24-8-4-2-6-22(24)25/h1-16H,17-18H2
InChI key	KHJFBUUFMUBONL-UHFFFAOYSA-N
originator	Merck & Co., Inc., Kenilworth, NJ, U.S.
Quality Level	100
SMILES string	O=C1c2ccccc2C(Cc3ccncc3)(Cc4ccncc4)c5ccccc15
solubility	DMSO: >20 mg/mL
storage temp.	2-8°C

Application:	XE-991 has been used as a KCNQ (Kv7.2/7.3) inhibitor to examine whether M-current inhibition affects oxytocin receptor (TGOT) mediated depolarization. It has also been used as an KCNQ inhibitor to study the ionic mechanism responsible for the overshoot/undershoot in membrane potential in mouse cholinergic interneurons (ChIs) in the presence of tetrodotoxin (TTX).
Biochem/physiol Actions:	XE-991 is a KCNQ channel blocker; which is more potent than linopiridine (Cat. No. L-134).
Features and Benefits:	This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Features and Benefits:	This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S. . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging:	10, 50 mg in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H315 - H319 - H335
Precautionary statements	P302 + P352 - P305 + P351 + P338
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

Choose a favorite list for this item:

Catalog Number	Description	Price

		$

Please choose a list :

Continue Shopping

Returns/Order support

Please fill out the form below if you want to request order support from Krackeler Scientific.