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XE-991

SIGMA/X2254 - ≥98% (HPLC)

Synonym: 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone

CAS Number: 122955-42-4
Empirical Formula (Hill Notation): C26H20N2O
Molecular Weight: 376.45
MDL Number: MFCD05662331
Linear Formula: C26H20N2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-X2254-10MG 10 mg
 $188.00
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45-X2254-50MG 50 mg
 $759.00
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assay ≥98% (HPLC)
color white to beige
InChI 1S/C26H20N2O/c29-25-21-5-1-3-7-23(21)26(17-19-9-13-27-14-10-19,18-20-11-15-28-16-12-20)24-8-4-2-6-22(24)25/h1-16H,17-18H2
InChI key KHJFBUUFMUBONL-UHFFFAOYSA-N
originator Merck & Co., Inc., Kenilworth, NJ, U.S.
Quality Level 100 
SMILES string O=C1c2ccccc2C(Cc3ccncc3)(Cc4ccncc4)c5ccccc15
solubility DMSO: >20 mg/mL
storage temp. 2-8°C
Application: XE-991 has been used as a KCNQ (Kv7.2/7.3) inhibitor to examine whether M-current inhibition affects oxytocin receptor (TGOT) mediated depolarization. It has also been used as an KCNQ inhibitor to study the ionic mechanism responsible for the overshoot/undershoot in membrane potential in mouse cholinergic interneurons (ChIs) in the presence of tetrodotoxin (TTX).
Biochem/physiol Actions: XE-991 is a KCNQ channel blocker.
Biochem/physiol Actions: XE-991 is a KCNQ channel blocker; which is more potent than linopiridine (Cat. No. L-134).
Features and Benefits: This compound is featured on the Potassium Channels  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Features and Benefits: This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S. . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 10, 50 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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