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XAV939

SIGMA/X3004 - ≥98% (HPLC)

Synonym: 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one

CAS Number: 284028-89-3
Empirical Formula (Hill Notation): C14H11F3N2OS
Molecular Weight: 312.31
MDL Number: MFCD16879017
Linear Formula: C14H11F3N2OS
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-X3004-5MG 5 mg
 $94.80
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45-X3004-25MG 25 mg
 $383.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: X3004-25MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: X3004-5MG

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C14H11F3N2OS/c15-14(16,17)9-3-1-8(2-4-9)12-18-11-5-6-21-7-10(11)13(20)19-12/h1-4H,5-7H2,(H,18,19,20)
InChI key KLGQSVMIPOVQAX-UHFFFAOYSA-N
Quality Level 100 
SMILES string FC(F)(F)c1ccc(cc1)C2=NC3=C(CSCC3)C(=O)N2
solubility DMSO: 5 mg/mL, clear
storage temp. room temp
Application: XAV939 has been used in the inhibition
•  of tankyrase in neuroblastoma cell lines
•  of diphtheria toxin-like ADP-ribosyltransferases (ARTD) in medulloblastoma cells
•  of wnt signalling in human induced pluripotent stem cells (hiPSCs)
Biochem/physiol Actions: XAV939 is a cell-permeable dihydrothiopyranopyrimidinol, which elicits anti-tumor functionality against colon, lung, breast and liver cancer. It binds to catalytic poly-ADP-ribose polymerase (PARP) domain of the tankyrase enzyme resulting in β-catenin destruction. It also inhibits tankyrase in neuroblastoma promoting apoptosis in tumor cells.
Biochem/physiol Actions: XAV939 is a Tankyrase inhibitor (thereby inhibiting Wnt / β-catenin signaling)
Features and Benefits: This compound is a featured product for Gene Regulation research. Click here  to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Other Notes: XAV939 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the XAV939 probe summary  on the Chemical Probes Portal website.
Packaging: 5, 25 mg in glass bottle
Hazard Codes T
Risk Statements 25-36
Safety Statements 26-45
RIDADR UN 2811 6.1 / PGIII
WGK Germany WGK 3
Purity ≥98% (HPLC)
Storage Temp. room temp
UNSPSC 12352200

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