Xanthine Oxidase from bovine milk
SIGMA/X4376 - lyophilized powder, 0.4-1.0 units/mg protein
Synonym: XOD; Xanthine:oxygen oxidoreductase
CAS Number: 9002-17-9
EC Number: 232-657-6
MDL Number: MFCD00082145
Product Type: Chemical
biological source | bovine milk |
composition | Protein, 10.0-25.0% |
form | lyophilized powder |
mol wt | 283 kDa |
Quality Level | 300 ![]() |
specific activity | 0.4-1.0 units/mg protein |
storage temp. | 2-8°C |
Analysis Note: | Protein determined by biuret |
Application: | Xanthine Oxidase from bovine milk has been used as a source for superoxide generation. It has also been used as a model enzyme in the internally calibrated electrochemical continuous enzyme assay (ICECEA). |
Biochem/physiol Actions: | The isoflavanoid genistein was shown to inhibit xanthine oxidase at concentrations between 0.1-4.0 μM and then activate xanthine oxidase at concentrations higher than 5 μM. |
Biochem/physiol Actions: | Xanthine Oxidase acts as a potential biomarker for oxidative stress. It is also implicated in tissue and vascular injuries such as liver damage, inflammatory diseases and chronic heart failure. |
Biochem/physiol Actions: | Xanthine oxidase is a molybdenum-containing enzyme that is found in the cytosol, and may be strongly inhibited by flavonoids. It plays a vital role in the metabolism of some drugs, as well as purines and pyrimidines. It is also known to be a biological source of reactive oxygen species. |
General description: | Formerly E.C. 1.1.3.22 |
Packaging: | 5, 25, 50 units in poly bottle |
Physical form: | Contains 0.5% sodium salicylate. |
Unit Definition: | One unit will convert 1.0 μmole of xanthine to uric acid per min at pH 7.5 at 25 °C. Approx. 50% of the activity is obtained with hypoxanthine as substrate. |
Symbol | ![]() |
Signal word | Danger |
Hazard statements | H334 |
Precautionary statements | P261 - P284 - P501 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
activity | specific activity: 0.4-1.0 units/mg protein |
Storage Temp. | 2-8°C |
Enzyme Commission (EC) Number | 1.17.3.2. |
UNSPSC | 12352204 |