Y-27632 dihydrochloride

SIGMA/Y0503 - ≥98% (HPLC)

Synonym: (R)-(+)-trans-4-(1-Aminoethyl)-N-(4-Pyridyl)cyclohexanecarboxamide dihydrochloride

CAS Number: 129830-38-2
Empirical Formula (Hill Notation): C₁₄H₂₁N₃O · 2HCl
Molecular Weight: 320.26
MDL Number: MFCD03490488
Linear Formula: C₁₄H₂₁N₃O · 2HCl
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-Y0503-1MG	1 mg	$232.00 1/EA	Add To Favorites
45-Y0503-5MG	5 mg	$795.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: Y0503-1MG

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
biological source	synthetic (organic)
color	white to beige
form	powder
InChI	1S/C14H21N3O.2ClH/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13;;/h6-12H,2-5,15H2,1H3,(H,16,17,18);2*1H/t10-,11-,12-;;/m1../s1
InChI key	IDDDVXIUIXWAGJ-LJDSMOQUSA-N
optical activity	[α]/D +3.0 to +5.0°, c = 1.0 in methanol
Quality Level	100
SMILES string	Cl.Cl.C[C@@H](N)[C@H]1CC[C@@H](CC1)C(=O)Nc2ccncc2
solubility	H₂O: 14 mg/mL
storage temp.	2-8°C

Application:	Y-27632 dihydrochloride has been used: • as a medium supplement in pancreatic ductal adenocarcinoma organoid culture • in the inhibition of Ras homolog gene family (Rho) kinase in mouse embryonic stem cells • in the inhibition of Rho-associated protein kinase (ROCK) in human embryonic stem cells and human induced pluripotent stem cells (iPSCs)
Biochem/physiol Actions:	Y-27632 is highly potent, cell-permeable, selective ROCK (Rho-associated coiled coil forming protein serine/threonine kinase) inhibitor. K_i = 140 nM for p160^ROCK. Y-27632 also inhibits ROCK-II with equal potency. The inhibition is competitive with respect to ATP.
Features and Benefits:	This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
General description:	Y-27632 dihydrochloride is an effective bronchodilator and improves lung resistance (RL) induced by antigen and acetylcholine. Y-27632 controls neutrophil migration and lung edema and may be a potential drug for treating acute lung injury.
Legal Information:	Sold under license from Mitsubishi Pharma Corporation
Packaging:	1, 5 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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