YM-202074 sesquifumarate salt hydrate

SIGMA/Y1271 - ≥98% (HPLC)

Synonym: N-cyclohexyl-6-{[(2-methoxyethyl)(methyl)amino]methyl}-N-methylthiazolo[3,2-a]benzimidazole-2-carboxamide; YM 202074; YM202074

CAS Number: 299900-84-8 (anhydrous)
Empirical Formula (Hill Notation): C₂₂H₃₀N₄O₂S · 1.5C₄H₄O₄ · xH₂O
Molecular Weight: 588.67 (anhydrous basis)
MDL Number: MFCD16879020
Linear Formula: C₂₂H₃₀N₄O₂S · 1.5C₄H₄O₄ · xH₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-Y1271-5MG	5 mg	$108.00 1/EA	Add To Favorites
45-Y1271-25MG	25 mg	$576.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to off-white
form	powder
InChI	1S/3C22H30N4O2S.2C4H4O4.H2O/c31-24(11-12-28-3)14-16-9-10-18-19(13-16)26-15-20(29-22(26)23-18)21(27)25(2)17-7-5-4-6-8-17;25-3(6)1-2-4(7)8;/h39-10,13,15,17H,4-8,11-12,14H2,1-3H3;21-2H,(H,5,6)(H,7,8);1H2/b;;;2*2-1+;
InChI key	MCGFIZFYSARKON-RAMYONIISA-N
Quality Level	100
SMILES string	O.OC(=O)C=CC(O)=O.OC(=O)C=CC(O)=O.COCCN(C)Cc1ccc2nc3sc(cn3c2c1)C(=O)N(C)C4CCCCC4.COCCN(C)Cc5ccc6nc7sc(cn7c6c5)C(=O)N(C)C8CCCCC8.COCCN(C)Cc9ccc%10nc%11sc(cn%11c%10c9)C(=O)N(C)C%12CCCCC%12
solubility	DMSO: >20 mg/mL
	H₂O: >5 mg/mL
storage temp.	room temp

Biochem/physiol Actions:	YM-202074 is a potent and selective allosteric metabotropic glutamate receptor type 1 (mGluR1) antagonist. It bound an allosteric site of rat mGluR1 with a Ki value of 4.8 nM. It also inhibited the mGluR1-mediated inositol phosphates production in rat cerebellar granule cells with an IC50 value of 8.6 nM, while showing selectivity over mGluR(2-7).
Packaging:	5, 25 mg in glass bottle

Symbol	GHS06
Signal word	Danger
Hazard statements	H301 - H319
Precautionary statements	P301 + P310 + P330 - P305 + P351 + P338
Hazard Codes	T
Risk Statements	25-36
Safety Statements	26-45
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	room temp
UNSPSC	12352200

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