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YM-58483

SIGMA/Y4895 - ≥98% (HPLC)

Synonym: 4-methyl-4′-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]-1,2,3-thiadiazole-5-carboxanilide

CAS Number: 223499-30-7
Empirical Formula (Hill Notation): C15H9F6N5OS
Molecular Weight: 421.32
MDL Number: MFCD00220976
Linear Formula: C15H9F6N5OS
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-Y4895-5MG 5 mg
 $221.00
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45-Y4895-25MG 25 mg
 $793.00
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assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C15H9F6N5OS/c1-7-12(28-25-23-7)13(27)22-8-2-4-9(5-3-8)26-11(15(19,20)21)6-10(24-26)14(16,17)18/h2-6H,1H3,(H,22,27)
InChI key XPRZIORDEVHURQ-UHFFFAOYSA-N
Quality Level 200 
SMILES string Cc1nnsc1C(=O)Nc2ccc(cc2)-n3nc(cc3C(F)(F)F)C(F)(F)F
solubility DMSO: 10 mg/mL, clear
storage temp. 2-8°C
Application: YM-58483 has been used in the inhibition studies of calcium channels present in cardiomyocytes and pulmonary arterial endothelial cells.
Biochem/physiol Actions: Selective store operated calcium (SOC) channel inhibitor.
Biochem/physiol Actions: YM-58483 is a selective Ca++ release-activated Ca++ (CRAC) [a.k.a. store-operated Ca++ (SOC) channels] that mediate Ca++ influx in T cells and other inflammatory cells. CRAC channel inhibitors have potential clinical applications in autoimmune disease, transplant rejection, allergic airway inflammation and bronchial asthma. YM-58483 is also promoted as a tool for CRAC studies; may be used as a gold standard.
Features and Benefits: This compound is featured on the Calcium Channels  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 25 mg in glass bottle
Hazard Codes Xn
Risk Statements 22-36/37/38
Safety Statements 26-36/37
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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