YM-58483
SIGMA/Y4895 - ≥98% (HPLC)
Synonym: 4-methyl-4′-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]-1,2,3-thiadiazole-5-carboxanilide
CAS Number: 223499-30-7
Empirical Formula (Hill Notation): C15H9F6N5OS
Molecular Weight: 421.32
MDL Number: MFCD00220976
Linear Formula: C15H9F6N5OS
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
InChI | 1S/C15H9F6N5OS/c1-7-12(28 |
InChI key | XPRZIORDEVHURQ-UHFFFAOYSA |
SMILES string | Cc1nnsc1C(=O)Nc2ccc(cc2)- |
solubility | DMSO: 10 mg/mL, clear |
storage temp. | 2-8°C |
Application: | YM-58483 has been used in the inhibition studies of calcium channels present in cardiomyocytes and pulmonary arterial endothelial cells. |
Biochem/physiol Actions: | YM-58483 is a selective Ca++ release-activated Ca++ (CRAC) [a.k.a. store-operated Ca++ (SOC) channels] that mediate Ca++ influx in T cells and other inflammatory cells. CRAC channel inhibitors have potential clinical applications in autoimmune disease, transplant rejection, allergic airway inflammation and bronchial asthma. YM-58483 is also promoted as a tool for CRAC studies; may be used as a gold standard. |
Features and Benefits: | This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
Packaging: | 5, 25 mg in glass bottle |
Hazard Codes | Xn |
Risk Statements | 22-36/37/38 |
Safety Statements | 26-36/37 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |