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Zatebradine hydrochloride

SIGMA/Z0127 - ≥98% (HPLC), powder

Synonym: 7,8-Dimethoxy-3-[3-[-N-[2-(3,4 dimethoxyphenyl)ethyl]-N-methylamino]propyl]-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one hydrochloride; UL-FS49

CAS Number: 91940-87-3
Empirical Formula (Hill Notation): C26H37ClN2O5
Molecular Weight: 493.04
MDL Number: MFCD06798356
Linear Formula: C26H37ClN2O5
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-Z0127-10MG 10 mg
 $276.00
1/EA		 Add To Favorites
45-Z0127-50MG 50 mg
 $1040.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white
form powder
InChI 1S/C26H36N2O5.ClH/c1-27(13-9-19-7-8-22(30-2)23(15-19)31-3)11-6-12-28-14-10-20-16-24(32-4)25(33-5)17-21(20)18-26(28)29;/h7-8,15-17H,6,9-14,18H2,1-5H3;1H
InChI key ZRNKXJHEQKMWCH-UHFFFAOYSA-N
originator Boehringer Ingelheim
Quality Level 100 
SMILES string Cl[H].COc1ccc(CCN(C)CCCN2CCc3cc(OC)c(OC)cc3CC2=O)cc1OC
solubility H2O: >10 mg/mL
storage condition desiccated
storage temp. 2-8°C
Application: Zatebradine hydrochloride has been used:
• as an If blocker to study its effects on cardiomyocyte clusters (CMCs)
• as a hyperpolarization-activated and cyclic nucleotide-gated (HCN) channel inhibitor to study its effects on viability of degenerating rod or cone photoreceptors in mice
• as a bradycardiac agent to study its effects on tachycardia and elevated temperature in fish

Biochem/physiol Actions: HCN channel blocker: blocker of neuronal Ih, related cardiac If channels and ATP-sensitive Kir channels.
Biochem/physiol Actions: Zatebradine is a bradycardiac agent.
Features and Benefits: This compound is a featured product for Cyclic Nucleotide research. Click here  to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound was developed by Boehringer Ingelheim . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 10, 50 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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