Zotepine

SIGMA/Z0877

Synonym: 2-[(8-chlorodibenzo[b,f]-thiepin-10-yl)oxy]-N,N-dimethylethanamine

CAS Number: 26615-21-4
Empirical Formula (Hill Notation): C₁₈H₁₈ClNOS
Molecular Weight: 331.86
MDL Number: MFCD00868143
Linear Formula: C₁₈H₁₈ClNOS
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-Z0877-10MG	10 mg	$88.80 1/EA		Add To Favorites
45-Z0877-50MG	50 mg	$269.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	>98% (HPLC)
color	white to off-white
form	powder
InChI	1S/C18H18ClNOS/c1-20(2)9-10-21-16-11-13-5-3-4-6-17(13)22-18-8-7-14(19)12-15(16)18/h3-8,11-12H,9-10H2,1-2H3
InChI key	HDOZVRUNCMBHFH-UHFFFAOYSA-N
originator	Astellas
Quality Level	100
SMILES string	CN(C)CCOC1=Cc2ccccc2Sc3ccc(Cl)cc13
solubility	DMSO: ≥20 mg/mL
storage temp.	room temp

Application:	Zotepine has been used as an anti-psychotic agent: • in biophysical studies with serotonin 2A receptor (5-HT_2AR) • to study its effects on the inhibition of human organic cation transporter 1 (hOCT1) • to study its protective effects on the human embryonic kidney (HEK cells)
Biochem/physiol Actions:	Zotepine acts as an antagonist of dopamine D1, D2, and serotonin (5-HT_2A/2C) receptors, and noradrenaline transporters. It shows therapeutic effects against schizophrenia and acute mania.
Biochem/physiol Actions:	Zotepine is an atypical antipsychotic.
Features and Benefits:	This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Features and Benefits:	This compound was developed by Astellas . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Other Notes:	Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. Z0877.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
Packaging:	10, 50 mg in glass bottle

Symbol	GHS07,GHS09
Signal word	Warning
Hazard statements	H302 - H400
Precautionary statements	P273
Hazard Codes	T
Risk Statements	25-50/53
Safety Statements	45-60-61
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	>98% (HPLC)
Storage Temp.	room temp
UNSPSC	12352200

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